Journal article
Obesity, Galectin-3, and Incident Heart Failure: The ARIC Study
Journal of the American Heart Association, v 11(9), pp e023238-e023238
03 May 2022
PMID: 35491999
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background Laboratory data suggest obesity is linked to myocardial inflammation and fibrosis, but clinical data are limited. We aimed to examine the association of obesity with galectin-3, a biomarker of cardiac inflammation and fibrosis, and the related implications for heart failure (HF) risk. Methods and Results We evaluated 8687 participants (mean age 63 years; 21% Black) at ARIC (Atherosclerosis Risk in Communities) Visit 4 (1996-1998) who were free of heart disease. We used adjusted logistic regression to estimate the association of body mass index (BMI) categories with elevated galectin-3 (≥75th sex-specific percentile) overall and across demographic subgroups, with tests for interaction. We used Cox proportional hazards models to assess the combined associations of galectin-3 and BMI with incident HF (through December 31, 2019). Higher BMI was associated with higher odds of elevated galectin-3 (odds ratio [OR], 2.32; 95% CI, 1.88-2.86) for severe obesity ([BMI ≥35 kg/m
] versus normal weight [BMI 18.5-<25 kg/m
]). There were stronger associations of BMI with elevated galectin-3 among women versus men and White versus Black participants (both
-for-interaction <0.05). Elevated galectin-3 was similarly associated with incident HF among people with and without obesity (HR, 1.49; 95% CI, 1.18-1.88; and HR, 1.71; 95% CI, 1.38-2.11, respectively). People with severe obesity and elevated galectin-3 had >4-fold higher risk of HF (HR, 4.19; 95% CI, 2.98-5.88) than those with normal weight and galectin-3 <25th percentile. Conclusions Obesity is strongly associated with elevated galectin-3. Additionally, the combination of obesity and elevated galectin-3 is associated with marked HF risk, underscoring the importance of elucidating pathways linking obesity with cardiac inflammation and fibrosis.
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Details
- Title
- Obesity, Galectin-3, and Incident Heart Failure: The ARIC Study
- Creators
- Roberta Florido - Johns Hopkins UniversityLucia Kwak - Bloomberg (United States)Justin B Echouffo-Tcheugui - Johns Hopkins University School of MedicineSui Zhang - Bloomberg (United States)Erin D Michos - Johns Hopkins UniversityVijay Nambi - Michael E. DeBakey VA Medical CenterRonald B Goldberg - University of MiamiRon C Hoogeveen - Baylor College of MedicineMariana Lazo - Drexel UniversityGary Gerstenblith - Johns Hopkins UniversityWendy S Post - Johns Hopkins UniversityRoger S Blumenthal - Johns Hopkins MedicineJosef Coresh - Bloomberg (United States)Aaron R Folsom - University of MinnesotaElizabeth Selvin - Bloomberg (United States)Christie Ballantyne - Baylor College of MedicineChiadi E Ndumele - Johns Hopkins University
- Publication Details
- Journal of the American Heart Association, v 11(9), pp e023238-e023238
- Grant note
- K24 HL152440 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000789861900002
- Scopus ID
- 2-s2.0-85129780785
- Other Identifier
- 991020550341604721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems