Logo image
Back
Obesity May Accelerate the Aging Process
Journal article   Open access   Peer reviewed

Obesity May Accelerate the Aging Process

Valentina Salvestrini, Christian Sell and Antonello Lorenzini
Frontiers in endocrinology (Lausanne), v 10(MAY), pp 266-266
03 May 2019
DOI: https://doi.org/10.3389/fendo.2019.00266
PMID: 31130916
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.3389/fendo.2019.00266View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

aging aging hallmarks caloric restriction Endocrinology obesity overweight
Lines of evidence from several studies have shown that increases in life expectancy are now accompanied by increased disability rate. The expanded lifespan of the aging population imposes a challenge on the continuous increase of chronic disease. The prevalence of overweight and obesity is increasing at an alarming rate in many parts of the world. Further to increasing the onset of metabolic imbalances, obesity leads to reduced life span and affects cellular and molecular processes in a fashion resembling aging. Nine key hallmarks of the aging process have been proposed. In this review, we will review these hallmarks and discuss pathophysiological changes that occur with obesity, that are similar to or contribute to those that occur during aging. We present and discuss the idea that obesity, in addition to having disease-specific effects, may accelerate the rate of aging affecting all aspects of physiology and thus shortening life span and health span.

Metrics

10 Record Views
169 citations in Web of Science
157 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Endocrinology & Metabolism
Logo image