Journal article
Obesity and Subtypes of Incident Cardiovascular Disease
Journal of the American Heart Association, v 5(8), pn/a
Aug 2016
PMID: 27468925
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Obesity is a risk factor for various subtypes of cardiovascular disease (CVD), including coronary heart disease (CHD), heart failure (HF), and stroke. Nevertheless, there are limited comparisons of the associations of obesity with each of these CVD subtypes, particularly regarding the extent to which they are unexplained by traditional CVD mediators.
We followed 13 730 participants in the Atherosclerosis Risk in Communities (ARIC) study who had a body mass index ≥18.5 and no CVD at baseline (visit 1, 1987-1989). We compared the association of higher body mass index with incident HF, CHD, and stroke before and after adjusting for traditional CVD mediators (including systolic blood pressure, diabetes mellitus, and lipid measures). Over a median follow-up of 23 years, there were 2235 HF events, 1653 CHD events, and 986 strokes. After adjustment for demographics, smoking, physical activity, and alcohol intake, higher body mass index had the strongest association with incident HF among CVD subtypes, with hazard ratios for severe obesity (body mass index ≥35 versus normal weight) of 3.74 (95% CI 3.24-4.31) for HF, 2.00 (95% CI 1.67-2.40) for CHD, and 1.75 (95% CI 1.40-2.20) for stroke (P<0.0001 for comparisons of HF versus CHD or stroke). Further adjustment for traditional mediators fully explained the association of higher body mass index with CHD and stroke but not with HF (hazard ratio 2.27, 95% CI 1.94-2.64).
The link between obesity and HF was stronger than those for other CVD subtypes and was uniquely unexplained by traditional risk factors. Weight management is likely critical for optimal HF prevention, and nontraditional pathways linking obesity to HF need to be elucidated.
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Details
- Title
- Obesity and Subtypes of Incident Cardiovascular Disease
- Creators
- Chiadi E Ndumele - Johns Hopkins UniversityKunihiro Matsushita - Bloomberg (United States)Mariana Lazo - Johns Hopkins UniversityNatalie Bello - Columbia University Irving Medical CenterRoger S Blumenthal - Johns Hopkins UniversityGary Gerstenblith - Johns Hopkins UniversityVijay Nambi - Michael E. DeBakey VA Medical CenterChristie M Ballantyne - Baylor College of MedicineScott D Solomon - Brigham and Women's HospitalElizabeth Selvin - Bloomberg (United States)Aaron R Folsom - University of MinnesotaJosef Coresh - Bloomberg (United States)
- Publication Details
- Journal of the American Heart Association, v 5(8), pn/a
- Grant note
- HHSN268201100005C / NHLBI NIH HHS HHSN268201100010C / NHLBI NIH HHS HHSN268201100007C / NHLBI NIH HHS K23 HL122447 / NHLBI NIH HHS HHSN268201100006C / NHLBI NIH HHS L30 HL129418 / NHLBI NIH HHS HHSN268201100008C / NHLBI NIH HHS HHSN268201100009C / NHLBI NIH HHS R01 DK089174 / NIDDK NIH HHS HHSN268201100011C / NHLBI NIH HHS HHSN268201100012C / NHLBI NIH HHS K24 DK106414 / NIDDK NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000386714900042
- Scopus ID
- 2-s2.0-85018710284
- Other Identifier
- 991020550498104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems