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Obesity, subclinical myocardial injury, and incident heart failure
Journal article   Open access   Peer reviewed

Obesity, subclinical myocardial injury, and incident heart failure

Chiadi E Ndumele, Josef Coresh, Mariana Lazo, Ron C Hoogeveen, Roger S Blumenthal, Aaron R Folsom, Elizabeth Selvin, Christie M Ballantyne and Vijay Nambi
JACC. Heart failure, v 2(6), pp 600-607
01 Dec 2014
DOI: https://doi.org/10.1016/j.jchf.2014.05.017
PMID: 25443112
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.jchf.2014.05.017View
Published, Version of Record (VoR) Open

Abstract

Biomarkers - metabolism Body Mass Index Cholesterol, LDL - metabolism Coronary Artery Disease - etiology Female Heart Failure - etiology Humans Male Middle Aged Myocardial Infarction - etiology Natriuretic Peptide, Brain - metabolism Obesity - complications Peptide Fragments - metabolism Prospective Studies Risk Factors Sex Factors Troponin T - metabolism Waist Circumference - physiology
The study sought to evaluate the association of obesity with a novel biomarker of subclinical myocardial injury, cardiac troponin T measured with a new high-sensitivity assay (hs-cTnT), among adults without clinical cardiovascular disease (CVD). Laboratory evidence suggests a relationship between obesity and myocardial injury that may play a role in the development of heart failure (HF), but there is limited clinical data regarding this association. We evaluated 9,507 participants in the ARIC (Atherosclerosis Risk in Communities) study without baseline CVD (Visit 4, 1996 to 1999). We assessed the cross-sectional association of body mass index (BMI) with high (≥14 ng/l) and measurable (≥3 ng/l) hs-cTnT levels after multivariable regression. We further evaluated the independent and combined associations of BMI and hs-cTnT with incident HF. Higher BMI was independently associated with a positive, linear increase in the likelihood of high hs-cTnT, with severe obesity (BMI >35 kg/m(2)) associated with an odds ratio of 2.20 (95% confidence interval: 1.59 to 3.06) for high hs-cTnT after adjustment. Over 12 years of follow-up, there were 869 incident HF events. Obesity and hs-cTnT were both independently associated with incident HF, and individuals with severe obesity and high hs-cTnT had a greater than 9-fold higher risk of incident HF (hazard ratio: 9.20 [95% confidence interval: 5.67 to 14.93]) than individuals with normal weight and undetectable hs-cTnT. Among individuals without CVD, higher BMI has an independent, linear association with subclinical myocardial injury, as assessed by hs-cTnT levels. Obesity and hs-cTnT provide independent and complementary prognostic information regarding the risk of incident HF.

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8 Record Views
101 citations in Web of Science
102 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
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