Journal article
Obesity susceptibility loci and dietary intake in the Look AHEAD Trial
The American journal of clinical nutrition, v 95(6), pp 1477-1486
01 Jun 2012
PMID: 22513296
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Genome-wide association studies (GWAS) have identified consistent associations with obesity. However, the mechanisms remain unclear.
Objective: The objective was to determine the association between obesity susceptibility loci and dietary intake.
Design: The association of GWAS-identified obesity risk alleles (FTO, MC4R, SH2B1, BDNF, INSIG2, TNNI3K, NISCH-STAB1, MTIF3, MAP2K5, QPCTL/GIPR, and PPARG) with dietary intake, measured through food-frequency questionnaires, was investigated in 2075 participants from the Look AHEAD (Action for Health in Diabetes) clinical trial. We adjusted for age, sex, population stratification, and study site.
Results: Obesity risk alleles at FTO rs1421085 significantly predicted more eating episodes per day (P = 0.001) an effect that persisted after adjustment for body weight (P = 0.004). Risk variants within BDNF were significantly associated with more servings from the dairy product and the meat, eggs, nuts, and beans food groups (P <= 0.004). The risk allele at SH2BI rs4788099 was significantly associated with more servings of dairy products (P = 0.001), whereas the risk allele at TNNI3K rs1514176 was significantly associated with a lower percentage of energy from protein (P = 0.002).
Conclusion: These findings suggest that obesity risk loci may affect the pattern and content of food consumption among overweight or obese individuals with type 2 diabetes. The Look AHEAD Genetic Ancillary Study was registered at clinicaltrials.gov as NCT01270763 and the Look AHEAD study as NCT00017953. Am J Clin Nutr 2012;95:1477-86.
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Details
- Title
- Obesity susceptibility loci and dietary intake in the Look AHEAD Trial
- Creators
- Jeanne M. McCaffery - Icahn School of Medicine at Mount SinaiGeorge D. Papandonatos - Icahn School of Medicine at Mount SinaiInga Peter - Icahn School of Medicine at Mount SinaiGordon S. Huggins - Icahn School of Medicine at Mount SinaiHollie A. Raynor - Icahn School of Medicine at Mount SinaiLinda M. Delahanty - Icahn School of Medicine at Mount SinaiLawrence J. Cheskin - Icahn School of Medicine at Mount SinaiAshok Balasubramanyam - Icahn School of Medicine at Mount SinaiLynne E. Wagenknecht - Icahn School of Medicine at Mount SinaiRena R. Wing - Icahn School of Medicine at Mount SinaiGenetic Subgrp Look AHEADEllen Stephanie Krauthamer Ewing - Drexel University
- Publication Details
- The American journal of clinical nutrition, v 95(6), pp 1477-1486
- Publisher
- AMER SOC NUTRITION-ASN
- Number of pages
- 10
- Grant note
- DK57136; DK57149; DK56990; DK57177; DK57171; DK57151; DK57182; DK57131; DK57002; DK57078; DK57154; DK57178; DK57219; DK57008; DK57135; DK56992 / Department of Health and Human Services through NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA M01RR01066 / Massachusetts General Hospital Mallinckrodt General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR02719 / Johns Hopkins Medical Institutions Bayview General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) M01RR01346 / Frederic C Banter General Clinical Research Center M01RR000056 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) U01DK057136 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) M01RR00051 / University of Colorado Health Sciences Center General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) University of Washington/VA Puget Sound Health Care System Medical Research Service, Department of Veterans Affairs; University of Washington; US Department of Veterans Affairs U01DK056992-11SI; DK072497 / Look AHEAD M01RR0021140 / University of Tennessee at Memphis General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) P30 DK48520 / Clinical Nutrition Research Unit M01RR000056 44 / University of Pittsburgh General Clinical Research Center; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) DK072497; DK 046204 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P20MD006899 / National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Counseling and Family Therapy; Drexel University
- Web of Science ID
- WOS:000304337600024
- Scopus ID
- 2-s2.0-84861536364
- Other Identifier
- 991020100187804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Nutrition & Dietetics