Journal article
Obstructive sleep apnea, nighttime arousals, and leukocyte telomere length: the Multi-Ethnic Study of Atherosclerosis
Sleep (New York, N.Y.), v 42(7)
08 Jul 2019
PMID: 30994174
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Sleep disturbances and sleep apnea are associated with increased vulnerability to age-related disease, altering molecular pathways affecting biological aging. Telomere length captures one component of biological aging. We evaluated whether objectively assessed sleep and sleep apnea relate to leukocyte telomere length (LTL) in the Multi-Ethnic Study of Atherosclerosis (MESA).
Men and women aged 44-84 years (n = 672) from the MESA Stress and MESA Sleep studies underwent polysomnography and 7 day actigraphy (at Exam 5) and assessment of LTL (at baseline [Exam 1] and about 10 years later [Exam 5]).
General linear models adjusting for age, sex, race/ethnicity, BMI, physical activity, and smoking found that severe obstructive sleep apnea (OSA; apnea-hypopnea index > 30) was cross-sectionally associated with shorter LTL (p = 0.007). Modest associations of shorter LTL with less rapid eye movement sleep, more stage 1 sleep, wake after sleep onset >30 min, and long sleep duration were found, but these effects were diminished after adjusting for lifestyle and OSA. Exploratory analyses found that higher arousal index at Exam 5 was associated with greater LTL decline over the prior 10 years (p = 0.004).
OSA was associated with shorter LTL. Individuals with high-arousal frequency had greater leukocyte telomere attrition over the prior decade. These findings suggest that sleep apnea and sleep fragmentation are associated with accelerated biological aging.
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Details
- Title
- Obstructive sleep apnea, nighttime arousals, and leukocyte telomere length: the Multi-Ethnic Study of Atherosclerosis
- Creators
- Judith E Carroll - Semel Institute for Neuroscience and Human BehaviorMichael R Irwin - Semel Institute for Neuroscience and Human BehaviorTeresa E Seeman - University of California, Los AngelesAna V Diez-Roux - Drexel UniversityAric A Prather - University of California SystemRichard Olmstead - Semel Institute for Neuroscience and Human BehaviorElissa Epel - University of California SystemJue Lin - University of California, San FranciscoSusan Redline - Beth Israel Deaconess Medical Center
- Publication Details
- Sleep (New York, N.Y.), v 42(7)
- Publisher
- Oxford University Press
- Grant note
- R01 HL098433 / NHLBI NIH HHS N01HC95169 / NHLBI NIH HHS N01HC95161 / NHLBI NIH HHS UL1 TR001881 / NCATS NIH HHS N01HC95164 / NHLBI NIH HHS N01HC95167 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS K01 AG044462 / NIA NIH HHS N01HC95163 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS R35 HL135818 / NHLBI NIH HHS R01 AG026364 / NIA NIH HHS UL1 TR001079 / NCATS NIH HHS UL1 TR000124 / NCATS NIH HHS R01 CA119159 / NCI NIH HHS N01HC95160 / NHLBI NIH HHS R01 HL076831 / NHLBI NIH HHS R01 AG034588 / NIA NIH HHS R01 CA160245 / NCI NIH HHS UL1 TR000040 / NCATS NIH HHS N01HC95168 / NHLBI NIH HHS R01 HL101161 / NHLBI NIH HHS R01 HL142051 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS N01HC95162 / NHLBI NIH HHS UL1 TR001420 / NCATS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000481491900009
- Scopus ID
- 2-s2.0-85068913106
- Other Identifier
- 991019168893204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences