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Obstructive sleep apnea syndrome and asthma: what are the links?
Journal article   Open access

Obstructive sleep apnea syndrome and asthma: what are the links?

Michel Alkhalil, Edward Schulman and Joanne Getsy
Journal of clinical sleep medicine, v 5(1)
15 Feb 2009
DOI: https://doi.org/10.5664/jcsm.27397
PMID: 19317386
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.5664/jcsm.27397View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Animals Asthma - complications Asthma - physiopathology Bronchi - blood supply Bronchoconstriction - physiology Comorbidity Dyspnea - physiopathology Gastroesophageal Reflux - complications Gastroesophageal Reflux - physiopathology Glottis - innervation Heart Failure - complications Heart Failure - physiopathology Humans Inflammation - complications Inflammation - physiopathology Laryngeal Nerves - physiopathology Leptin - physiology Neovascularization, Pathologic - physiopathology Reflex, Abnormal - physiology Risk Factors Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - physiopathology Vagus Nerve - physiopathology Vascular Endothelial Growth Factor A - physiology Weight Gain - physiology
Recent data suggest that obstructive sleep apnea syndrome (OSAS) is an independent risk factor for asthma exacerbations. Neuromechanical reflex bronchoconstriction, gastroesophageal reflux, inflammation (local and systemic), and the indirect effect on dyspnea of OSAS-induced cardiac dysfunction have been suggested as mechanisms that lead to worsening asthma control in patients with concomitant OSAS. Vascular endothelial growth factor-induced airway angiogenesis, leptin-related airway changes, and OSAS-induced weight gain also may play a common mechanistic role linking both disorders. Several studies have confirmed that asthmatic patients are more prone to develop OSAS symptoms than are members of the general population. The common asthmatic features that promote OSAS symptoms are nasal obstruction, a decrease in pharyngeal cross sectional area, and an increase in upper airway collapsibility. Clarifying the nature of the relationship between OSAS and asthma is a critical area with important therapeutic implications.

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130 citations in Web of Science
138 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Web of Science research areas
Clinical Neurology
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