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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State
Occupational and environmental medicine (London, England), v 67(6), pp 375-386
Jun 2010
PMID: 19819864
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
ObjectiveTo identify potential risk factors for serum cholinesterase (BuChE) inhibition among agricultural pesticide handlers exposed to organophosphate (OP) and N-methyl-carbamate (CB) insecticides.MethodsWe conducted a longitudinal study among 154 agricultural pesticide handlers who participated in the Washington State cholinesterase monitoring program in 2006 and 2007. BuChE inhibition was analysed in relation to reported exposures before and after adjustment for potential confounders using linear regression. ORs estimating the risk of BuChE depression (>20% from baseline) were also calculated for selected exposures based on unconditional logistic regression analyses.ResultsAn overall decrease in mean BuChE activity was observed among study participants at the time of follow-up testing during the OP/CB spray season relative to pre-season baseline levels (mean decrease of 5.6%, p<0.001). Score for estimated cumulative exposure to OP/CB insecticides in the past 30 days was a significant predictor of BuChE inhibition (β=−1.74, p<0.001). Several specific work practices and workplace conditions were associated with greater BuChE inhibition, including mixing/loading pesticides and cleaning spray equipment. Factors that were protective against BuChE inhibition included full-face respirator use, wearing chemical-resistant boots and storing personal protective equipment in a locker at work.ConclusionsDespite existing regulations, agricultural pesticide handlers continue to be exposed to OP/CB insecticides at levels resulting in BuChE inhibition. These findings suggest that modifying certain work practices could potentially reduce BuChE inhibition. Replication from other studies will be valuable.
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Details
- Title
- Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State
- Creators
- Jonathan N Hofmann - University of WashingtonMatthew C Keifer - University of WashingtonAnneclaire J De Roos - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaRichard A Fenske - University of WashingtonClement E Furlong - University of WashingtonGerald van Belle - University of WashingtonHarvey Checkoway - University of Washington
- Publication Details
- Occupational and environmental medicine (London, England), v 67(6), pp 375-386
- Publisher
- British Medical Journal (BMJ)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000278353900005
- Scopus ID
- 2-s2.0-77953758516
- Other Identifier
- 991020100086604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health