Journal article
Occupational exposure to pesticides and risk of adult brain tumors
American journal of epidemiology, v 167(8), pp 976-985
15 Apr 2008
PMID: 18299277
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The authors examined incident glioma and meningioma risk associated with occupational exposure to insecticides and herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 glioma and 195 meningioma patients diagnosed between 1994 and 1998 in three US hospitals. Controls were 765 patients admitted to the same hospitals for nonmalignant conditions. Occupational histories were collected during personal interviews. Exposure to pesticides was estimated by use of a questionnaire, combined with pesticide measurement data abstracted from published sources. Using logistic regression models, the authors found no association between insecticide and herbicide exposures and risk for glioma and meningioma. There was no association between glioma and exposure to insecticides or herbicides, in men or women. Women who reported ever using herbicides had a significantly increased risk for meningioma compared with women who never used herbicides (odds ratio = 2.4, 95% confidence interval: 1.4, 4.3), and there were significant trends of increasing risk with increasing years of herbicide exposure (p = 0.01) and increasing cumulative exposure (p = 0.01). There was no association between meningioma and herbicide or insecticide exposure among men. These findings highlight the need to go beyond job title to elucidate potential carcinogenic exposures within different occupations.
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Details
- Title
- Occupational exposure to pesticides and risk of adult brain tumors
- Creators
- Claudine M. Samanic - Division of Cancer Epidemiology and Genetics, National Cancer Institute/National Institutes of Health/Department of Health and Human Services, Bethesda, MDAnneclaire J. De Roos - Fred Hutchinson Cancer Research CenterPatricia A. Stewart - Division of Cancer Epidemiology and Genetics, National Cancer Institute/National Institutes of Health/Department of Health and Human Services, Bethesda, MDPreetha Rajaraman - Division of Cancer Epidemiology and Genetics, National Cancer Institute/National Institutes of Health/Department of Health and Human Services, Bethesda, MDMartha A. Waters - National Institute for Occupational Safety and HealthPeter D. Inskip - Division of Cancer Epidemiology and Genetics, National Cancer Institute/National Institutes of Health/Department of Health and Human Services, Bethesda, MD
- Publication Details
- American journal of epidemiology, v 167(8), pp 976-985
- Publisher
- Oxford Univ Press
- Number of pages
- 10
- Grant note
- N01-CP-15679-01 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Z01CP010135 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) ZIA CP010135-18 / Intramural NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000254874900012
- Scopus ID
- 2-s2.0-42049099680
- Other Identifier
- 991020099457104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health