Journal article
Occupational exposures and ovarian cancer in textile workers
Epidemiology (Cambridge, Mass.), v 19(2)
01 Mar 2008
PMID: 18300714
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Occupational risk factors for ovarian cancer have been investigated only to a limited extent. We conducted a case-cohort study to examine associations between occupational exposures and ovarian cancer in the textile industry.
Methods: We compared 261 incident ovarian cancer cases diagnosed between 1989 and 1998 with an age-stratified refer nee subcohort (n = 3199) from a cohort of 267,400 textile workers in Shanghai, China. Occupational exposures were assessed by job-exposure matrices designed for the textile industry, and estimates of quantitative cotton dust and endotoxin. We calculated hazard ratios (HRs) and 95% confidence intervals (CIs) with Cox proportional hazards modeling adapted for the case-cohort design.
Results: A decreased risk of ovarian cancer was associated with ever having worked in cotton manufacturing production (HR = 0.7; 95% CI = 0.4-1.0). An increased risk was associated with ever having worked in textile finishing (2.1; 0.9-5.0). We found an increasing risk of ovarian cancer associated with cumulative exposure to silica dust (for <10 years exposure, HR = 6.8 [CI = 0.6-76]; for >= 10 years, 5.6 [1.3-23.6]), although these results are based on only 8 exposed subcohort women (0.3%) and 4 cases (1.3%). We also detected inverse risk gradients for cumulative exposures to endotoxin when exposures were lagged by 20 years (in highest quartile, HR = 0.6 [CI = 0.4-1.1]).
Conclusion: Silica dust may increase the risk of ovarian cancer, and cotton dust and endotoxin may reduce risk.
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Details
- Title
- Occupational exposures and ovarian cancer in textile workers
- Creators
- Karen J. Wernli - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaRoberta M. Ray - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaDao Li Gao - Fudan UniversityE. Dawn Fitzgibbons - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaJanice E. Camp - University of WashingtonGeorge Astrakianakis - University of WashingtonNoah Seixas - University of WashingtonEva Y. Wong - University of WashingtonWenjin Li - University of WashingtonAnneclaire J. De Roos - University of WashingtonZiding Feng - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaDavid B. Thomas - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaHarvey Checkoway - University of Washington
- Publication Details
- Epidemiology (Cambridge, Mass.), v 19(2)
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000253401400013
- Scopus ID
- 2-s2.0-39149114074
- Other Identifier
- 991020100065304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health