Journal article
Occupational insecticide exposure and risk of non-Hodgkin lymphoma: A pooled case-control study from the InterLymph Consortium
International journal of cancer, v 149(10), pp 1768-1786
15 Nov 2021
PMID: 34270795
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Evidence for the human health effects of pesticides is needed to inform risk assessment. We studied the relationship between occupational insecticide use and risk of non-Hodgkin lymphoma (NHL) by pooling data from nine case-control studies participating in the InterLymph Consortium, including 7909 cases and 8644 controls from North America, the European Union and Australia. Insecticide use was coded using self-report or expert assessment, for insecticide groups (eg, organophosphates, pyrethroids) and active ingredients (eg, malathion, permethrin). Associations with insecticides were estimated using logistic regression to produce odds ratios (ORs) and 95% confidence intervals (CI) for all NHL and NHL subtypes, with adjustment for study site, demographic factors and use of other pesticides. Occupational insecticide use, overall, was not associated with risk of NHL. Use of organophosphate insecticides was associated with increased risk of all NHL and the subtype follicular lymphoma, and an association was found with diazinon, in particular (ever use: OR = 2.05, 95%CI: 1.24-3.37). The carbamate insecticide, carbaryl, was associated with risk of all NHL, and the strongest associations were found with T-cell NHL for ever-use (OR = 2.44, 95%CI: 1.13-5.28) and longer duration (>8 years vs never: OR = 2.90, 95%CI: 1.02-8.25). There was no association of NHL with other broad groups of insecticides, including organochlorines and pyrethroids, and some inverse associations were estimated in relation to historical DDT use. Our findings contribute to the totality of evidence available to help inform risk decisions by public health and regulatory agencies of importance given continued, widespread use of organophosphate and carbamate insecticides.
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Details
- Title
- Occupational insecticide exposure and risk of non-Hodgkin lymphoma: A pooled case-control study from the InterLymph Consortium
- Creators
- Anneclaire J De Roos - Drexel UniversityLeah H Schinasi - Drexel UniversityLucia Miligi - Environmental and Occupational Epidemiology Branch, Institute for Cancer Research Prevention and Clinical Network (ISPRO) Florence ItalyJames R Cerhan - Division of Epidemiology, Department of Quantitative Health Sciences Mayo Clinic Rochester Minnesota USAParveen Bhatti - University of British ColumbiaAndrea 't Mannetje - Center for Public Health Research, Massey University-Wellington Campus, Wellington, New ZealandDalsu Baris - University of MinnesotaYolanda Benavente - Instituto de Salud Carlos IIIGeza Benke - Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, AustraliaJacqueline Clavel - SorbonneDelphine Casabonne - Instituto de Salud Carlos IIILin Fritschi - Monash UniversityJonathan N Hofmann - National Cancer InstituteTran Huynh - Drexel UniversityAlain Monnereau - SorbonneSara Piro - Environmental and Occupational Epidemiology Branch, Institute for Cancer Research Prevention and Clinical Network (ISPRO) Florence ItalySusan L Slager - Division of Computational Biology and Hematology, Department of Quantitative Health Sciences and Medicine Mayo Clinic Rochester Minnesota USAClaire M Vajdic - UNSW SydneySophia S Wang - Division of Health Analytics, Department of Computational and Quantitative Medicine City of Hope Comprehensive Cancer Center Duarte California USAYawei Zhang - National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, ChinaLeslie Bernstein - City of HopePierluigi Cocco - University of Manchester
- Publication Details
- International journal of cancer, v 149(10), pp 1768-1786
- Publisher
- Wiley
- Grant note
- R03 CA199515 / NCI NIH HHS R03CA199515 / National Cancer Institute (NCI) of the National Institutes of Health (NIH) R01CA92153 / National Cancer Institute (NCI) of the National Institutes of Health (NIH) P50CA97274 / National Cancer Institute (NCI) of the National Institutes of Health (NIH)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000698647200005
- Scopus ID
- 2-s2.0-85111520820
- Other Identifier
- 991019168781804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Oncology