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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Occupational risk factors for endometrial cancer among textile workers in Shanghai, China
American journal of industrial medicine, v 51(9), pp 673-679
01 Sep 2008
PMID: 18626909
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective A case-cohort study was conducted to investigate associations between occupational exposures and endometrial cancer nested within a large cohort of textile workers in Shanghai, China.
Methods The study included 176 incident endometrial cancer cases diagnosed from 1989 to 1998 and a randomly-selected age-stratified reference subcohort (n=3,061). Study subjects' complete work histories were linked to a job-exposure matrix developed specifically for the textile industry to assess occupational exposures. Hazard ratios (HR) and 95% confidence intervals were calculated using Cox proportional hazards modeling adapted for the case-cohort design, adjusting for age at menarche and a composite variable of gravidity and parity.
Results An increased risk of endometrial cancer was detected among women who had worked for >= 10 years in silk production (HR = 3.8, 95% CI 1.2-11.8) and had exposure to silk dust (HR =1.7,95% CI 0.9-3.4). Albeit with few exposed women (two cases and eight subcohort women), there was a 7.4 fold increased risk associated with >= 10 years of silica dust exposure (95% CI 1.4-39.7).
Conclusions The findings suggest that some textile industry exposures might play a role in endometrial carcinoma and should be further replicated in other occupational settings.
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Details
- Title
- Occupational risk factors for endometrial cancer among textile workers in Shanghai, China
- Creators
- Karen J. Wernli - University of WashingtonRoberta M. Ray - Fred Hutch Cancer CenterDao Li Gao - Zhongshan HospitalE. Dawn Fitzgibbons - Fred Hutch Cancer CenterJanice E. Camp - University of WashingtonGeorge Astrakianakis - University of WashingtonNoah Seixas - University of WashingtonWenjin Li - University of WashingtonAnneclaire J. De Roos - Fred Hutchinson Cancer Research CenterZiding Feng - University of WashingtonDavid B. Thomas - University of WashingtonHarvey Checkoway - University of Washington
- Publication Details
- American journal of industrial medicine, v 51(9), pp 673-679
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- R01 CA080180-03; R01 CA080180; R01 CA080180-01A1; R01 CA080180-02; R01 CA080180-04; R01 CA80180 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) R01CA080180 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) T32 ES007262; T32 ES007262-13; T32 ES007262-14; T32 ES007262-15; T32 ES007262-15S1; T32 ES007262-15S2; T32 ES007262-12; ES07262 / NIEHS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) T32ES007262 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000258418500006
- Scopus ID
- 2-s2.0-49649098864
- Other Identifier
- 991020099053604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health