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Octreotide promotes gallbladder absorption in prairie dogs: A potential cause of gallstones
Journal article   Open access   Peer reviewed

Octreotide promotes gallbladder absorption in prairie dogs: A potential cause of gallstones

A.James Moser, Mohammad Z. Abedin, Dan I.N. Giurgiu and Joel J. Roslyn
Gastroenterology (New York, N.Y. 1943), v 108(5), pp 1547-1555
1995
DOI: https://doi.org/10.1016/0016-5085(95)90705-X
PMID: 7729647
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/0016-5085(95)90705-xView
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Isc V t DIDS R t
Background/Aims Gallstone formation during octreotide administration has been causally linked to increased biliary concentrations of calcium, protein, and total lipids, all purported prolithogenic factors. These changes may be caused by octreotide-induced gallbladder stasis or a direct effect of octreotide on gallbladder absorption. We tested the hypothesis that octreotide stimulates gallbladder ion and water transport. Methods Prairie dog gallbladders were mounted in Ussing chambers and bathed in oxygenated Ringer's solution. Electrophysiological parameters were recorded, and unidirectional Na +, Cl −, and H 2O fluxes were measured before and after serosal exposure to 50 nmol/L octreotide. Results Octreotide exposure caused a significant decrease in transepithelial short-circuit current and potential difference and an increase in tissue resistance compared with baseline. These alterations in electrophysiological parameters coincided with changes in ion transport. Octreotide stimulated net Na + and H 2O absorption and converted the gallbladder from a state of Cl − secretion to one of Cl − absorption by increasing mucosal to serosal fluxes. Octreotide effects on ion transport were blocked by 4,4′-diisothiocynostilbene2,2′-disulfonic acid and amiloride and reversed by theophylline. Conclusions Octreotide may promote gallstone formation by inducing gallbladder stasis and by directly increasing gallbladder absorption, which may act synergistically to increase the concentration of prolithogenic factors in bile and to facilitate nucleation and stone growth.

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Collaboration types
Domestic collaboration
Web of Science research areas
Gastroenterology & Hepatology
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