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Of Mice and Melanoma
Journal article   Open access   Peer reviewed

Of Mice and Melanoma

Edward J. Hartsough and Andrew E. Aplin
Clinical cancer research, v 22(7), pp 1550-1552
03 Feb 2016
PMID: 26842234
url
https://doi.org/10.1158/1078-0432.ccr-15-3054View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze) Open
url
https://doi.org/10.1158/1078-0432.CCR-15-3054View
Published, Version of Record (VoR) Open

Abstract

Targeted therapies have advanced the treatment options for cutaneous melanoma but many patients will progress on drug. Patient-derived xenografts (PDX) can be used to recapitulate therapy resistant tumors. Furthermore, PDX modeling can be utilized in combination with targeted sequencing and phospho-proteomic platforms providing pre-clinical basis for second-line targeted inhibitor strategies.

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8 citations in Scopus

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Web of Science research areas
Oncology
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