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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder
Journal of autism and developmental disorders, v 50(8), pp 2685-2697
Aug 2020
PMID: 31960263
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Olfactory dysfunction is recognized in neurodevelopmental disorders and may serve as an early indicator of global dysfunction. The present meta-analysis measures olfaction effect sizes in attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), and obsessive-compulsive disorder (OCD). Meta-analysis included 320 ADHD, 346 ASD, and 208 OCD individuals as compared to 910 controls. Olfactory performance deficits were small-to-moderate and heterogeneous (d = - 0.42, 95% CI = - 0.59 < δ < - 0.25). Meta-analytic results indicate that olfactory dysfunction is evident in individuals with ASD and OCD, with small-to-negligible effects in ADHD. These findings imply olfactory dysfunction is related to clinical phenotype in ASD and OCD, but not ADHD, and warrant inclusion in clinical assessment and evaluation of certain neurodevelopmental disorders.
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Details
- Title
- Olfactory Dysfunction in Neurodevelopmental Disorders: A Meta-analytic Review of Autism Spectrum Disorders, Attention Deficit/Hyperactivity Disorder and Obsessive-Compulsive Disorder
- Creators
- Andrew J D Crow - University of PennsylvaniaJennica M Janssen - Drexel UniversityKayci L Vickers - University of PennsylvaniaJulia Parish-Morris - Children's Hospital of PhiladelphiaPaul J Moberg - University of PennsylvaniaDavid R Roalf - Children's Hospital of Philadelphia
- Publication Details
- Journal of autism and developmental disorders, v 50(8), pp 2685-2697
- Publisher
- Springer Nature
- Grant note
- R21 MH108895 / NIMH NIH HHS K01 MH102609 / NIMH NIH HHS R01 MH119185 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000550772400004
- Scopus ID
- 2-s2.0-85078242844
- Other Identifier
- 991019168270804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychology, Developmental