Journal article
Oligometastatic Parathyroid Carcinoma Presenting as Neck Pain: A Case Report
Ear, nose, & throat journal, v 102(10), pp 635-639
01 Oct 2023
PMID: 34041944
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Parathyroid carcinoma (PC) is an exceedingly rare, slow-growing but progressive endocrine malignancy that represents a diagnostic and therapeutic challenge. Vertebral metastasis of PC is remarkable, with only 3 prior cases of spinal metastasis reported in the literature. Case Description: A 62-year-old woman presented with 1 week of neck pain radiating down her right arm. Cervical x-ray revealed a lytic lesion of the C4 vertebral body. Lab work revealed hypercalcemia with an elevated parathyroid hormone level. Computed tomography and magnetic resonance imaging revealed frank destruction of the C4 vertebral body and pedicles by PC. She was treated with corpectomy, mass excision, anterior cervical discectomy and fusion, postoperative radiotherapy, and nonspecific inhibitors of active tumor pathways. Her symptoms resolved postoperatively, and she has remained negative for reoccurrence at 15-month follow-up. Conclusions: To the authors' knowledge, we report the first described cervical spine metastasis of PC. Additionally, we review the treatment of this rare neoplasm in an extremely rare location in the age of tumor sequencing and morphoproteomic analysis.
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Details
- Title
- Oligometastatic Parathyroid Carcinoma Presenting as Neck Pain: A Case Report
- Creators
- Katherine M. Yu - The University of Texas Health Science Center at HoustonDuncan J. Trimble - The University of Texas Health Science Center at HoustonChristopher R. Conner - The University of Texas Health Science Center at HoustonDallas L. Sheinberg - The University of Texas Health Science Center at HoustonGarren M. I. Low - The University of Texas Health Science Center at HoustonKaran Saluja - The University of Texas Health Science Center at HoustonKarl M. Schmitt - The University of Texas Health Science Center at HoustonRon J. Karni - The University of Texas Health Science Center at Houston
- Publication Details
- Ear, nose, & throat journal, v 102(10), pp 635-639
- Publisher
- Sage
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000680605400001
- Scopus ID
- 2-s2.0-85106577609
- Other Identifier
- 991022008088304721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Otorhinolaryngology