Logo image
Back
On the Organization of the Locomotor CPG: Insights From Split-Belt Locomotion and Mathematical Modeling
Journal article   Open access   Peer reviewed

On the Organization of the Locomotor CPG: Insights From Split-Belt Locomotion and Mathematical Modeling

Elizaveta M. Latash, Charly G. Lecomte, Simon M. Danner, Alain Frigon, Ilya A. Rybak and Yaroslav I. Molkov
Frontiers in neuroscience, v 14, pp 598888-598888
16 Oct 2020
DOI: https://doi.org/10.3389/fnins.2020.598888
PMID: 33177987
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.3389/fnins.2020.598888View
Published, Version of Record (VoR)CC BY V4.0,  Open

Abstract

central pattern generator locomotion modeling neural circuits Neuroscience split-belt
Rhythmic limb movements during locomotion are controlled by central pattern generator (CPG) circuits located in the spinal cord. It is considered that these circuits are composed of individual rhythm generators (RGs) for each limb interacting with each other through multiple commissural and long propriospinal circuits. The organization and operation of each RG are not fully understood, and different competing theories exist about interactions between its flexor and extensor components, as well as about left–right commissural interactions between the RGs. The central idea of circuit organization proposed in this study is that with an increase of excitatory input to each RG (or an increase in locomotor speed) the rhythmogenic mechanism of the RGs changes from “flexor-driven” rhythmicity to a “classical half-center” mechanism. We test this hypothesis using our experimental data on changes in duration of stance and swing phases in the intact and spinal cats walking on the ground or tied-belt treadmills (symmetric conditions) or split-belt treadmills with different left and right belt speeds (asymmetric conditions). We compare these experimental data with the results of mathematical modeling, in which simulated CPG circuits operate in similar symmetric and asymmetric conditions with matching or differing control drives to the left and right RGs. The obtained results support the proposed concept of state-dependent changes in RG operation and specific commissural interactions between the RGs. The performed simulations and mathematical analysis of model operation under different conditions provide new insights into CPG network organization and limb coordination during locomotion.

Metrics

8 Record Views
11 citations in Web of Science
9 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Neurosciences
Logo image