Journal article
On the Post-Compaction Evolution of Tensile Strength of Sodium Chloride-Starch Mixture Tablets
Journal of pharmaceutical sciences, v 106(8), pp 2088-2096
01 Aug 2017
PMID: 28495565
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study focuses on the evolution of mechanical behavior of starch and sodium chloride (NaCl) mixture tablets after compaction. This type of mixture has attracted attention in the past because such tablets exhibit lower tensile strengths than the ones of its individual components. Here we demonstrate that the strengths of NaCl-starch mixtures and NaCl tablets evolve after compaction in an opposite way. When stored at relative humidity of 60%, NaCl tablets strengthen with time, whereas NaCl-starch mixtures weaken. To explain this behavior, we propose that in the NaCl-starch mixture, the presence of 2 materials with significantly different elastic moduli leads to creation of tensile stresses at the stiffer NaCl-NaCl contacts. Such tensile stresses lead to a reduction in strength of the compacted mixtures by negating a local dissolution-reprecipitation mechanism, which strengthens the NaCl-NaCl in pure NaCl tablet. This effect is proven by experimental results from NaCl specimens diametrically loaded during storage. (C) 2017 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
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Details
- Title
- On the Post-Compaction Evolution of Tensile Strength of Sodium Chloride-Starch Mixture Tablets
- Creators
- Jovana Radojevic - Drexel UniversityAntonios Zavaliangos - Drexel University
- Publication Details
- Journal of pharmaceutical sciences, v 106(8), pp 2088-2096
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- International Fine Particles Research Institute (IFPRI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000417339200018
- Scopus ID
- 2-s2.0-85020519328
- Other Identifier
- 991019168957404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Multidisciplinary
- Pharmacology & Pharmacy