Journal article
On the Relative Effects of Wall and Intraluminal Thrombus Constitutive Material Properties in Abdominal Aortic Aneurysm Wall Stress
Cardiovascular engineering and technology
28 Oct 2024
PMID: 39466593
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An abdominal aortic aneurysm (AAA) is a dilation localized in the infrarenal segment of the abdominal aorta that can expand continuously and rupture if left untreated. Computational methods such as finite element analysis (FEA) are widely used with in silico models to calculate biomechanical predictors of rupture risk while choosing constitutive material properties for the AAA wall and intraluminal thrombus (ILT).
In the present work, we investigated the effect of different constitutive material properties for the wall and ILT on 21 idealized and 10 unruptured patient-specific AAA geometries. Three material properties were used to characterize the wall and two for the ILT, leading to six material model combinations for each AAA geometry subject to appropriate boundary conditions.
The results of the FEA simulations indicate significant differences in the average peak wall stress (PWS), 99th percentile wall stress (99th WS), and spatially averaged wall stress (SAWS) for all AAA geometries subject to the choice of a material model combination. Specifically, using a material model combination with a compliant ILT yielded statistically higher wall stresses compared to using a stiff ILT, irrespective of the constitutive equation used to model the AAA wall.
This work provides quantitative insight into the variability of the wall stress distributions ensuing from AAA FEA modeling due to its strong dependency on population-averaged soft tissue material characterizations. This dependency leads to uncertainty about the true biomechanical state of stress of an individual AAA and the subsequent assessment of its rupture risk.
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Details
- Title
- On the Relative Effects of Wall and Intraluminal Thrombus Constitutive Material Properties in Abdominal Aortic Aneurysm Wall Stress
- Creators
- Vivian Reyna - The University of Texas at San AntonioNiusha Fathesami - The University of Texas at San AntonioWei Wu - University of MiamiSatish C Muluk - Allegheny General HospitalVictor De Oliveira - The University of Texas at San AntonioEnder A Finol - The University of Texas at San Antonio
- Publication Details
- Cardiovascular engineering and technology
- Publisher
- SPRINGER; NEW YORK
- Number of pages
- 13
- Grant note
- R01HL159300 / NHLBI NIH HHS N/A / The Zachry Distinguished Professorship in Engineering
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:001344338300001
- Scopus ID
- 2-s2.0-85207540807
- Other Identifier
- 991021944492204721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Engineering, Biomedical