Journal article
On the rapid in situ oxidation of two-dimensional V2CTz MXene in culture cell media and their cytotoxicity
Materials Science & Engineering C, v 119, 111431
Feb 2021
PMID: 33321581
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The plethora of emerging two-dimensional (2D) materials exhibit wide potential application in novel technologies and advanced devices. However, their stability in environmental conditions could be an issue, affecting their application possibilities and posing health risks. Moreover, their decomposed leftovers can also induce a negative influence on human health. In particular, transition metal carbides commonly referred to as MXenes are susceptible to environmental oxidation being decomposed toward transition metal oxides and carbide-derived carbon. In this study we focused on the oxidation-state-related in vitro cytotoxicity of delaminated V2CTz onto immortalized keratinocytes (HaCaT) and malignant melanoma (A375) human cell lines. Due to the fact, that the V2CTx MXenes are least stable from all known obtained MXenes up to date, the vanadium ones were a practical choice to visualize the oxidation-cytotoxic correlation keeping the standards of 24–48 h of cell culturing. We found that the oxidation of V2CTz highly increases their cytotoxicity toward human cells, which is also time and dose dependent. The identified mode of action relates to the cell cycle as well as cellular membrane disintegration through direct physicochemical interactions.
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•2D nano-sheets of V2CTz MXene constantly oxidize in cell culture media.•Cytotoxicity of the V2CTz 2D flakes was directly related to their extent of oxidation in the cell culture.•Non-toxic V2CTz turns highly toxic when oxidized.•The decrease in cells' viabilities was dose, time, and oxidation dependent.•Mode of action refers to cell cycle, cellular membrane integrity.
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Details
- Title
- On the rapid in situ oxidation of two-dimensional V2CTz MXene in culture cell media and their cytotoxicity
- Creators
- A.M. Jastrzębska - Warsaw University of TechnologyB. Scheibe - Adam Mickiewicz University in PoznańA. Szuplewska - Warsaw University of TechnologyA. Rozmysłowska-Wojciechowska - Warsaw University of TechnologyM. Chudy - Warsaw University of TechnologyC. Aparicio - Regional Centre of Advanced Technologies and MaterialsM. Scheibe - Regional Centre of Advanced Technologies and MaterialsI. Janica - Adam Mickiewicz University in PoznańA. Ciesielski - Adam Mickiewicz University in PoznańM. Otyepka - Regional Centre of Advanced Technologies and MaterialsM.W. Barsoum - Drexel University
- Publication Details
- Materials Science & Engineering C, v 119, 111431
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000600887700002
- Scopus ID
- 2-s2.0-85090239458
- Other Identifier
- 991019168106304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Materials Science, Biomaterials