Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids

Ridhdhi Desai; Ling Huang; Raul S Gonzalez; Senthil K Muthuswamy

doi:10.1158/1541-7786.MCR-23-0199

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Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids

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Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids

Ridhdhi Desai, Ling Huang, Raul S Gonzalez and Senthil K Muthuswamy

Molecular cancer research, v 22(5), pp 440-451

02 May 2024

DOI: https://doi.org/10.1158/1541-7786.MCR-23-0199

PMID: 38319286

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Abstract

Acinar Cells - metabolism

Acinar Cells - pathology

Carcinoma, Pancreatic Ductal - genetics

Carcinoma, Pancreatic Ductal - metabolism

Carcinoma, Pancreatic Ductal - pathology

Cell Proliferation

Chromogranins - genetics

Chromogranins - metabolism

Cyclic AMP-Dependent Protein Kinases - genetics

Cyclic AMP-Dependent Protein Kinases - metabolism

GTP-Binding Protein alpha Subunits, Gs - genetics

GTP-Binding Protein alpha Subunits, Gs - metabolism

Humans

Organoids - metabolism

Organoids - pathology

Pancreatic Ducts - cytology

Pancreatic Ducts - metabolism

Pancreatic Ducts - pathology

Pancreatic Neoplasms - genetics

Pancreatic Neoplasms - metabolism

Pancreatic Neoplasms - pathology

The study identifies an opportunity to discover a PKA-independent pathway downstream of oncogene GNAS for managing IPMN lesions and their progression to PDAC.

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7 citations in Web of Science

7 citations in Scopus

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Title: Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids
Creators: Ridhdhi Desai - Beth Israel Deaconess Medical Center
Ling Huang - Beth Israel Deaconess Medical Center
Raul S Gonzalez - Beth Israel Deaconess Medical Center
Senthil K Muthuswamy - Cancer Genetics (United States)
Publication Details: Molecular cancer research, v 22(5), pp 440-451
Publisher: American Association for Cancer Research (AACR)
Grant note: F32 GM115201 / NIGMS NIH HHS Z99 CA999999 / Intramural NIH HHS
Resource Type: Journal article
Language: English
Academic Unit: Biochemistry and Molecular Biology
Web of Science ID: WOS:001225904500005
Scopus ID: 2-s2.0-85192113162
Other Identifier: 991022035262804721

UN Sustainable Development Goals (SDGs)

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Collaboration types: Domestic collaboration
Web of Science research areas: Cell Biology; Oncology

Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids

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Abstract

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UN Sustainable Development Goals (SDGs)

InCites Highlights

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