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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Oncologic outcomes and patient-reported quality of life in patients with oropharyngeal squamous cell carcinoma treated with definitive transoral robotic surgery versus definitive chemoradiation
Oral oncology, v 61, pp 41-46
01 Oct 2016
PMID: 27688103
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•CRT and definitive TORS offer similar oncologic outcomes in early stage OPSCC.•TORS resulted in improved short and long-term saliva-related QOL compared to CRT.•Use of adjuvant therapy after TORS lead to worse saliva and taste-related QOL.•Use of TORS and N classification were significant predictors of saliva-related QOL.
It has been postulated that treatment outcomes are similar between transoral robotic surgery (TORS) and definitive chemoradiation (CRT) for oropharyngeal squamous cell carcinomas (OPSCC). We compared oncologic and quality of life (QOL) outcomes between definitive CRT and definitive TORS.
An observational comparison study was performed on 92 patients treated with TORS±adjuvant therapy and 46 patients treated with definitive CRT between July 2005 and January 2016. The Kaplan Meier method was used for survival analyses, and the Mann-Whitney test was used to compare QOL scores between groups.
All patients had T0-T2 and N0-N2 disease, although CRT patients had higher clinical staging (p<0.001). HPV+ disease was present in 79% (n=73) of TORS patients and 91% (n=19) of tested CRT patients. Median follow-up was 22.1months (range: 0.33–83.4). There were no significant differences in locoregional control or overall survival between CRT and TORS groups. Definitive TORS resulted in better saliva-related QOL than definitive CRT at 1, 6, 12, and 24months (p<0.001, p=0.025, p=0.017, p=0.011). Among TORS patients, adjuvant therapy was associated with worse QOL in the saliva domain at 6, 12, and 24months (p<0.001, p<0.001, p=0.007), and taste domain at 6 and 12months (p=0.067, p=0.008).
Definitive CRT and definitive TORS offer similar rates of locoregional control, overall survival, and disease-free survival in patients with early stage OPSCC. TORS resulted in significantly better short and long-term saliva-related QOL, whereas adjuvant therapy was associated with worse saliva and taste-related QOL compared to TORS alone.
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Details
- Title
- Oncologic outcomes and patient-reported quality of life in patients with oropharyngeal squamous cell carcinoma treated with definitive transoral robotic surgery versus definitive chemoradiation
- Creators
- D.C. Ling - UPMC Hillman Cancer CenterB.V. Chapman - UPMC Hillman Cancer CenterJ. Kim - University of Pittsburgh Medical CenterG.W. Choby - University of Pittsburgh Medical CenterP. Kabolizadeh - UPMC Hillman Cancer CenterD.A. Clump - UPMC Hillman Cancer CenterR.L. Ferris - University of Pittsburgh Medical CenterS. Kim - University of Pittsburgh Medical CenterS. Beriwal - UPMC Hillman Cancer CenterD.E. Heron - UPMC Hillman Cancer CenterU. Duvvuri - University of Pittsburgh Medical Center
- Publication Details
- Oral oncology, v 61, pp 41-46
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000384695400007
- Scopus ID
- 2-s2.0-84983396066
- Other Identifier
- 991021897395104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Dentistry, Oral Surgery & Medicine
- Oncology