Files and links (2)
Published, Version of Record (VoR)CC BY-NC-ND V4.0, Open
Journal article
One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function
Journal of the American Heart Association, v 5(8), pn/a
27 Jul 2016
PMID: 27464788
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Despite public awareness that tobacco secondhand smoke (SHS) is harmful, many people still assume that marijuana SHS is benign. Debates about whether smoke-free laws should include marijuana are becoming increasingly widespread as marijuana is legalized and the cannabis industry grows. Lack of evidence for marijuana SHS causing acute cardiovascular harm is frequently mistaken for evidence that it is harmless, despite chemical and physical similarity between marijuana and tobacco smoke. We investigated whether brief exposure to marijuana SHS causes acute vascular endothelial dysfunction.
We measured endothelial function as femoral artery flow-mediated dilation (FMD) in rats before and after exposure to marijuana SHS at levels similar to real-world tobacco SHS conditions. One minute of exposure to marijuana SHS impaired FMD to a comparable extent as impairment from equal concentrations of tobacco SHS, but recovery was considerably slower for marijuana. Exposure to marijuana SHS directly caused cannabinoid-independent vasodilation that subsided within 25 minutes, whereas FMD remained impaired for at least 90 minutes. Impairment occurred even when marijuana lacked cannabinoids and rolling paper was omitted. Endothelium-independent vasodilation by nitroglycerin administration was not impaired. FMD was not impaired by exposure to chamber air.
One minute of exposure to marijuana SHS substantially impairs endothelial function in rats for at least 90 minutes, considerably longer than comparable impairment by tobacco SHS. Impairment of FMD does not require cannabinoids, nicotine, or rolling paper smoke. Our findings in rats suggest that SHS can exert similar adverse cardiovascular effects regardless of whether it is from tobacco or marijuana.
Metrics
Details
- Title
- One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function
- Creators
- Xiaoyin Wang - University of California, San FranciscoRonak Derakhshandeh - University of California, San FranciscoJiangtao Liu - Division of Cardiology, University of California, San Francisco Department of Cardiovascular Surgery & Electro-chemotherapy, China-Japan Friendship Hospital, Beijing, People's Republic of ChinaShilpa Narayan - University of California, San FranciscoPooneh Nabavizadeh - University of California, San FranciscoStephenie Le - University of California, San FranciscoOlivia M Danforth - University of California, San FranciscoKranthi Pinnamaneni - University of California, San FranciscoHilda J Rodriguez - Broad CenterEmmy Luu - University of California, San FranciscoRichard E Sievers - University of California, San FranciscoSuzaynn F Schick - University of California, San FranciscoStanton A Glantz - University of California, San FranciscoMatthew L Springer - University of California, San FranciscoXuehang Wang - A.J. Drexel Nanomaterials Institute
- Publication Details
- Journal of the American Heart Association, v 5(8), pn/a
- Grant note
- R21 DA031966 / NIDA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Nanomaterials Institute
- Web of Science ID
- WOS:000386714900038
- Scopus ID
- 2-s2.0-84989879766
- Other Identifier
- 991019173521904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems