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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Online fronto-cortical control of simple and attention-demanding locomotion in humans
NeuroImage (Orlando, Fla.), v 112, pp 152-159
15 May 2015
PMID: 25765257
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Knowledge of online functional brain mechanisms of locomotion is scarce due to technical limitations of traditional neuroimaging methods. Using functional Near Infrared Spectroscopy (fNIRS) we evaluated task-related changes in oxygenated hemoglobin levels (HbO2) in real-time over the pre-frontal-cortex (PFC) regions during simple (Normal Walk; NW) and attention-demanding (Walking While Talking; WWT) locomotion tasks in a large cohort of non-demented older adults. Results revealed that the assessment of task-related changes in HbO2 was internally consistent. Imposing greater demands on the attention system during locomotion resulted in robust bilateral PFC increases in HbO2 levels during WWT compared to NW and the cognitive interference tasks. Elevated PFC oxygenation levels were maintained throughout the course of WWT but not during the NW condition. Increased oxygenation levels in the PFC were related to greater stride length and better cognitive performance but not to faster gait velocity in WWT. These findings elucidate online brain mechanisms of locomotion, and confer significant implications for risk assessment and intervention for major mobility outcomes.
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Details
- Title
- Online fronto-cortical control of simple and attention-demanding locomotion in humans
- Creators
- Roee Holtzer - Albert Einstein College of MedicineJeannette R Mahoney - Albert Einstein College of MedicineMeltem Izzetoglu - Drexel UniversityCuiling Wang - Albert Einstein College of MedicineSarah England - Yeshiva UniversityJoe Verghese - Albert Einstein College of MedicineChen Wang - Marketing
- Publication Details
- NeuroImage (Orlando, Fla.), v 112, pp 152-159
- Publisher
- Elsevier
- Grant note
- R01AG036921 / NIA NIH HHS R01 AG036921 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Marketing
- Web of Science ID
- WOS:000353203400015
- Scopus ID
- 2-s2.0-84925159162
- Other Identifier
- 991019173554904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging