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Opiate-associated contextual memory formation and retrieval are differentially modulated by dopamine D1 and D2 signaling in hippocampal-prefrontal connectivity
Journal article   Open access   Peer reviewed

Opiate-associated contextual memory formation and retrieval are differentially modulated by dopamine D1 and D2 signaling in hippocampal-prefrontal connectivity

Yunpeng Wang, Hongying Zhang, Jingjing Cui, Jing Zhang, Fangyuan Yin, Hao Guo, Jianghua Lai and Bo Xing
Neuropsychopharmacology (New York, N.Y.), v 44(2), pp 334-343
Jan 2019
DOI: https://doi.org/10.1038/s41386-018-0068-y
PMID: 29728647
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1038/s41386-018-0068-yView
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Analgesics, Opioid - administration & dosage Animals Association Learning - drug effects Conditioning, Classical - drug effects Cyclic AMP Response Element-Binding Protein - metabolism Glycogen Synthase Kinase 3 - metabolism Hippocampus - drug effects Hippocampus - metabolism Male Memory - drug effects Memory - physiology Mice Morphine - administration & dosage Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Signal Transduction - drug effects
Contextual memory driven by abused drugs such as opiates has a central role in maintenance and relapse of drug-taking behaviors. Although dopamine (DA) signaling favors memory storage and retrieval via regulation of hippocampal-prefrontal connectivity, its role in modulating opiate-associated contextual memory is largely unknown. Here, we report roles of DA signaling within the hippocampal-prefrontal circuit for opiate-related memories. Combining-conditioned place preference (CPP) with molecular analyses, we investigated the DA D1 receptor (D1R) and extracellular signal-regulated kinase (ERK)-cAMP-response element binding protein (CREB) signaling, as well as DA D2 receptor (D2R) and protein kinase B (PKB or Akt)/glycogen synthase kinase 3 (GSK3) signaling in the ventral hippocampus (vHip) and medial prefrontal cortex (mPFC) during the formation of opiate-related associative memories. Morphine-CPP acquisition increased the activity of the D1R-ERK-CREB pathway in both the vHip and mPFC. Morphine-CPP reinstatement was associated with the D2R-mediated hyperactive GSK3 via Akt inhibition in the vHip and PFC. Furthermore, integrated D1R-ERK-CREB and D2R-Akt-GSK3 pathways in the vHip-mPFC circuit are required for the acquisition and retrieval of the morphine contextual memory, respectively. Moreover, blockage of D1R or D2R signaling could alleviate normal Hip-dependent spatial memory. These results suggest that D1R and D2R signaling are differentially involved in the acquisition and retrieval of morphine contextual memory, and DA signaling in the vHip-mPFC connection contributes to morphine-associated and normal memory, largely depending on opiate exposure states.

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Collaboration types
Domestic collaboration
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Web of Science research areas
Neurosciences
Pharmacology & Pharmacy
Psychiatry
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