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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program
Journal of exposure science & environmental epidemiology, v 30(3), pp 397-419
01 May 2020
PMID: 32066883
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Environmental Influences on Child Health Outcomes (ECHO) Program will evaluate environmental factors affecting children's health (perinatal, neurodevelopmental, obesity, respiratory, and positive health outcomes) by pooling cohorts composed of >50,000 children in the largest US study of its kind. Our objective was to identify opportunities for studying chemicals and child health using existing or future ECHO chemical exposure data. We described chemical-related information collected by ECHO cohorts and reviewed ECHO-relevant literature on exposure routes, sources, and environmental and human monitoring. Fifty-six ECHO cohorts have existing or planned chemical biomonitoring data for mothers or children. Environmental phenols/parabens, phthalates, metals/metalloids, and tobacco biomarkers are each being measured by >= 15 cohorts, predominantly during pregnancy and childhood, indicating ample opportunities to study child health outcomes. Cohorts are collecting questionnaire data on multiple exposure sources and conducting environmental monitoring including air, dust, and water sample collection that could be used for exposure assessment studies. To supplement existing chemical data, we recommend biomonitoring of emerging chemicals, nontargeted analysis to identify novel chemicals, and expanded measurement of chemicals in alternative biological matrices and dust samples. ECHO's rich data and samples represent an unprecedented opportunity to accelerate environmental chemical research to improve the health of US children.
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Details
- Title
- Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program
- Creators
- Jessie P. Buckley - Bloomberg (United States)Emily S. Barrett - Rutgers, The State University of New JerseyPaloma I. Beamer - University of ArizonaDeborah H. Bennett - University of California, DavisMichael S. Bloom - SUNY Albany, Dept Environm Hlth Sci, Albany, NY 12222 USATimothy R. Fennell - RTI InternationalRebecca C. Fry - University of North Carolina at Chapel HillWilliam E. Funk - Northwestern UniversityGhassan B. Hamra - Bloomberg (United States)Stephen S. Hecht - University of MinnesotaKurunthachalam Kannan - New York State Department of HealthRamsunder Iyer - Northwestern Univ, Northwestern University, Feinberg School of Medicine, Dept Prevent Med, Feinberg Sch MedMargaret R. Karagas - Dartmouth CollegeKristen Lyall - Drexel UniversityPatrick J. Parsons - University at Albany, State University of New YorkEdo D. Pellizzari - RTI InternationalAntonio J. Signes-Pastor - Dartmouth CollegeAnne P. Starling - Colorado School of Public HealthAolin Wang - University of California, San FranciscoDeborah J. Watkins - University of MichiganMingyu Zhang - Bloomberg (United States)Tracey J. Woodruff - University of California, San FranciscoProgram Collaborators ECHO
- Publication Details
- Journal of exposure science & environmental epidemiology, v 30(3), pp 397-419
- Publisher
- Springer Nature
- Number of pages
- 23
- Grant note
- U2COD023375; U24OD023382; UG3OD023305; UH3OD023305; UG3OD023271; UH3OD023271; UG3OD023349; UH3OD023349; UG3OD023282; UG3OD023365; UH3OD023365; UG3OD023316; U2CES026544; UG3OD023348; UH3OD023348 / ECHO program, Office of The Director, NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01DK076648 / NIDDK; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) RD-83544201; RD 83543301 / US EPA; United States Environmental Protection Agency P01ES022841; R01ES027051; P30 ES005022; R00ES025817; P01ES022832 / NIEHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000514049300002
- Scopus ID
- 2-s2.0-85079713851
- Other Identifier
- 991020100088004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology