Journal article
Opposite effects of acute and repeated administration of desmethylimipramine on adrenergic responsiveness in rat pineal gland
Life sciences (1973), v 24(24), pp 2237-2244
11 Jun 1979
PMID: 228145
Abstract
The effect of acute and repeated desmethylimipramine (DMI) treatment on catecholamine-stimulated production of adenosine 3', 5'-monophosphate (cyclic AMP) in rat pineal gland was studied
in
vivo
. In rats exposed to continuous illumination, the administration of isoproterenol (2μmol/kg) to control animals produced a marked increase in the concentration of cyclic AMP in pineal gland. In contrast, norepinephrine (2μmol/kg) failed to increase the levels of cyclic AMP. After acute treatment with DMI (single injection, 38μmol/kg, i. p.), the isoproterenol-induced rise in cyclic AMP was not significantly different from that measured in control animals. However, acute DMI treatment did allow a significant elevation in the concentration of cyclic AMP in pineal gland in response to norepinephrine. In rats given nine injections of DMI (38μmol/kg, i.p., twice daily) neither isoproterenol nor norepinephrine caused a significant increase in the concentration of cyclic AMP in pineal glands. Although acute treatment with DMI had no significant effect on [
3H] dihydroalprenolol binding, chronic treatment with DMI significantly reduced [
3H] dihydroalprenolol binding in the pineal gland. The results of this study suggest that while a single administration of DMI can enhance adrenergic responses elicited by norepinephrine, chronic administration of DMI leads to compensatory decreases in receptor density and adrenergic responsiveness.
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Details
- Title
- Opposite effects of acute and repeated administration of desmethylimipramine on adrenergic responsiveness in rat pineal gland
- Creators
- John A. Moyer - University of PennsylvaniaLouise H. Greenberg - Department of Pharmacology, Medical College of Pennsylvania, Philadelphia, Pa. 19129, USAAlan Frazer - University of PennsylvaniaDavid J. Brunswick - University of PennsylvaniaJoe Mendels - University of PennsylvaniaBenjamin Weiss - Department of Pharmacology, Medical College of Pennsylvania, Philadelphia, Pa. 19129, USA
- Publication Details
- Life sciences (1973), v 24(24), pp 2237-2244
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1979GZ83200005
- Scopus ID
- 2-s2.0-0018664772
- Other Identifier
- 991020836355104721