Journal article
Optic Nerve Tilt, Crescent, Ovality, and Torsion in a Multi-Ethnic Cohort of Young Adults With and Without Myopia
Investigative ophthalmology & visual science, v 58(7), pp 3158-3171
01 Jun 2017
PMID: 28654981
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The purpose of this article is to evaluate optic nerve head (ONH) characteristics in an ethnically diverse cohort of young U.S. adults.
In this study, 409 myopes and 206 nonmyopes (median age 22 years) completed measures including biometry and spectral domain optical coherence tomography from enface (ovality and torsion) and cross-sectional (tilt and crescent width) scans. Associated factors were evaluated using multivariable models.
In myopic versus nonmyopic right eyes, median tilt (6.0° vs. 2.4°; P < 0.0001) and frequency of crescents (49% vs. 10%; P < 0.0001) were higher in myopes. Right eyes with crescents had higher median tilts (8.8° [myopic], 9.0° [nonmyopic]) than those without crescent (2.5° [myopic], 2.1° [nonmyopic]), irrespective of refractive group (both P < 0.0001). Torsion was similar between groups, with a slight difference in ovality (0.89 vs. 0.91; P < 0.03). Data in the left eyes were similar, and modeling was done only for the right myopic eyes. Multivariable models showed that an increased tilt was associated with ethnicity (P < 0.001), the presence of crescent (P < 0.001), and smaller ONH diameter (P < 0.0031), with interactions between ethnicity and crescent (P = 0.002). Specifically, ONH tilt was significantly higher in Asian eyes without crescent (P < 0.0001 for all comparisons), and crescent width was associated with increased tilt in non-Asian eyes (P < 0.02). Crescent width was associated with ethnicity (greatest in Asians) and disc tilt. Interactions were observed between tilt and ethnicity, whereby tilt had a greater effect on crescent width in non-Asian eyes, and crescent width was associated with increased tilt in non-Asian eyes.
The data clarify the influence of ethnicity and myopia on ONH characteristics in young adults and may inform future studies of biomechanical properties or of retinal pathology of the myopic eye.
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Details
- Title
- Optic Nerve Tilt, Crescent, Ovality, and Torsion in a Multi-Ethnic Cohort of Young Adults With and Without Myopia
- Creators
- Wendy L Marsh-Tootle - University of Alabama at BirminghamElise Harb - University of California, BerkeleyWei Hou - Stony Brook MedicineQinghua Zhang - Stony Brook MedicineHeather A Anderson - University of HoustonKatherine Weise - University of Alabama at BirminghamThomas T Norton - University of Alabama at BirminghamJane Gwiazda - New England College of OptometryLeslie Hyman - Stony Brook MedicineCorrection of Myopia Evaluation Trial (COMET) Study GroupMitchell Scheiman - Pennsylvania College of Optometry (PCO)
- Publication Details
- Investigative ophthalmology & visual science, v 58(7), pp 3158-3171
- Publisher
- ARVO
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:000404959300037
- Scopus ID
- 2-s2.0-85021954514
- Other Identifier
- 991021900020304721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology