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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists
International journal of radiation oncology, biology, physics, v 108(1), pp 227-241
01 Sep 2020
PMID: 32417409
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Immunotherapy using immune checkpoint blockade has revolutionized the treatment of many types of cancer. Radiation therapy (RT)—particularly when delivered at high doses using newer techniques—may be capable of generating systemic antitumor effects when combined with immunotherapy in breast cancer. These systemic effects might be due to the local immune-priming effects of RT resulting in the expansion and circulation of effector immune cells to distant sites. Although this concept merits further exploration, several challenges need to be overcome. One is an understanding of how the heterogeneity of breast cancers may relate to tumor immunogenicity. Another concerns the need to develop knowledge and expertise in delivery, sequencing, and timing of RT with immunotherapy. Clinical trials addressing these issues are under way. We here review and discuss the particular opportunities and issues regarding this topic, including the design of informative clinical and translational studies.
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Details
- Title
- Optimizing Radiation Therapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists
- Creators
- Alice Y. Ho - Massachusetts General HospitalJean L. Wright - Department of Radiation Oncology, Johns Hopkins Cancer Center, Brooklandville, MarylandRachel C. Blitzblau - Duke Medical CenterRobert W. Mutter - Mayo ClinicDan G. Duda - Massachusetts General HospitalLarry Norton - Memorial Sloan Kettering Cancer CenterAditya Bardia - Massachusetts General HospitalLaura Spring - Massachusetts General HospitalSteven J. Isakoff - Massachusetts General HospitalJonathan H. Chen - Massachusetts General HospitalClemens Grassberger - Massachusetts General HospitalJennifer R. Bellon - Dana-Farber Cancer InstituteSushil Beriwal - UPMC Hillman Cancer CenterAtif J. Khan - Memorial Sloan Kettering Cancer CenterCorey Speers - University of Michigan–Ann ArborSamantha A. Dunn - Massachusetts General HospitalAlastair Thompson - Baylor College of MedicineCesar A. Santa-Maria - Johns Hopkins MedicineIan E. Krop - Dana-Farber Cancer InstituteElizabeth Mittendorf - Dana-Farber Cancer InstituteTari A. King - Dana-Farber Cancer InstituteGaorav P. Gupta - University of North Carolina at Chapel Hill
- Publication Details
- International journal of radiation oncology, biology, physics, v 108(1), pp 227-241
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:000561895300027
- Scopus ID
- 2-s2.0-85089232864
- Other Identifier
- 991021897394604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Radiology, Nuclear Medicine & Medical Imaging