Journal article
Optimizing an extended care intervention to promote weight loss maintenance: Protocol for the OPT-X multiphase optimization strategy factorial trial
Contemporary clinical trials, v 170, 108448
27 Aug 2026
PMID: 42660284
Abstract
Weight loss maintenance (WLM) remains a limitation of behavioral obesity interventions, as long-term adherence is burdensome and diminishes over time. Simplified recommendations and/or alternative delivery methods that target evidence-based WLM strategies may reduce burden to improve long-term outcomes.
This protocol describes a multiphase optimization strategy (MOST) trial using a 2x2x2x2 factorial design to optimize a 12-month extended care program for weight loss maintenance. Adults with obesity who achieve at least 5% weight loss during an initial 4-month behavioral weight loss program are randomized to receive a core maintenance program plus zero to four "minimally disruptive" intervention components: reduced food variety, home-based resistance training, buddy training and support, and acceptance and commitment therapy workshops.
The primary outcome is weight loss maintenance at 12 months following randomization. Secondary outcomes include treatment adherence, treatment burden, behavioral maintenance constructs, and hypothesized mediators and moderators of intervention effects.
This study explores unconventional but evidence-based treatment strategies for WLM and applies a 'minimally disruptive medicine' paradigm to behavioral maintenance. These findings have the potential to inform best practices for the provision of WLM interventions, improve long-term outcomes for individuals accessing weight management services, and strengthen the overall public health impact of available interventions for disease prevention and management.
NCT, NCT06785064. Registered [01/15/2025], https://clinicaltrials.gov/study/NCT06785064?term=NCT06785064&rank=1.
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Details
- Title
- Optimizing an extended care intervention to promote weight loss maintenance: Protocol for the OPT-X multiphase optimization strategy factorial trial
- Creators
- Gareth R Dutton (Corresponding Author) - University of Alabama at BirminghamAmber W Kinsey - University of Alabama at BirminghamRikki M Tanner - University of Alabama at BirminghamOlivia Krantz - University of Alabama at BirminghamAmy Dobelstein - University of Alabama at BirminghamChaoling Dong - University of Alabama at BirminghamNavneet Baidwan - University of Alabama at BirminghamTapan Mehta - University of Alabama at BirminghamMeghan L Butryn - Drexel UniversityHollie A Raynor - University of Tennessee at KnoxvilleBonnie Spring - Florida State University
- Publication Details
- Contemporary clinical trials, v 170, 108448
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- National Institute on Minority Health and Health Disparities: P50MD017338 National Institute of Diabetes and Digestive and Kidney Diseases: R01DK139059, P30DK056336 National Center for Advancing Translational Sciences of the National Institutes of Health (NIH): K12TR004769
This publication was supported by the following award numbers: P50MD017338 from the National Institute on Minority Health and Health Disparities, R01DK139059 and P30DK056336 from the National Institute of Diabetes and Digestive and Kidney Diseases, and K12TR004769 from the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH) . The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:001864785000001
- Other Identifier
- 991022203460204721