Journal article
Optimizing the Treatment of CRPS With Ketamine
The Clinical journal of pain, v 36(7), pp 516-523
01 Jul 2020
PMID: 32243301
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: This study aimed to develop a method that objectively measures the clinical benefits of ketamine infusions to treat complex regional pain syndrome (CRPS), thus making it possible, for the first time, to determine the optimal dosing of ketamine and duration of treatment to treat CRPS. Materials and Methods: All patients were diagnosed with hyperalgesia associated with CRPS. Patients underwent an outpatient, 4-day, escalating dose ketamine infusion. Hyperalgesia was measured using pain thresholds. Clinical outcome was determined without knowledge of the patient's pain thresholds throughout treatment. Results: We found a correlation between pain thresholds and the intensity of pain reported by the patient at various sites of the body. We found that clinical outcomes correlated with improvement in pain thresholds. There was a plateau in pain thresholds between days 3 and 4 for the lower extremities. There was no plateau in pain thresholds observed for the upper extremities. Discussion: Our findings suggest that 4 days of treatment are sufficient for the treatment of CRPS of the lower extremities. For the upper extremities, >4 days may be required. Our study is the first to utilize quantitative sensory testing to direct the treatment of a chronic pain disorder.
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Details
- Title
- Optimizing the Treatment of CRPS With Ketamine
- Creators
- Anthony F. Kirkpatrick - The International Research Foundation for RSD/CRPS, Tampa.Abolfazl Saghafi - Department of Mathematics, Physics and Statistics, University of the Sciences.Kai Yang - Departments of Biostatistics.Peihua Qiu - Departments of Biostatistics.James Alexander - University of FloridaEgle Bavry - University of FloridaRobert Schwartzman - Drexel University
- Publication Details
- The Clinical journal of pain, v 36(7), pp 516-523
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 8
- Grant note
- International Research Foundation for RSD/CRPS headquartered in Tampa, FL
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000542770200003
- Scopus ID
- 2-s2.0-85083467035
- Other Identifier
- 991019167837004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Anesthesiology
- Clinical Neurology