Journal article
Optogenetic Activation of Excitatory Premotor Interneurons Is Sufficient to Generate Coordinated Locomotor Activity in Larval Zebrafish
The Journal of neuroscience, v 34(1), pp 134-139
01 Jan 2014
PMID: 24381274
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neural networks in the spinal cord can generate locomotion in the absence of rhythmic input from higher brain structures or sensory feedback because they contain an intrinsic source of excitation. However, the molecular identity of the spinal interneurons underlying the excitatory drive within the locomotor circuit has remained unclear. Using optogenetics, we show that activation of a molecularly defined class of ipsilateral premotor interneurons elicits locomotion. These interneurons represent the excitatory module of the locomotor networks and are sufficient to produce a coordinated swimming pattern in zebrafish. They correspond to the V2a interneuron class and express the transcription factor Chx10. They produce sufficient excitatory drive within the spinal networks to generate coordinated locomotor activity. Therefore, our results define the V2a interneurons as the excitatory module within the spinal locomotor networks that is sufficient to initiate and maintain locomotor activity.
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Details
- Title
- Optogenetic Activation of Excitatory Premotor Interneurons Is Sufficient to Generate Coordinated Locomotor Activity in Larval Zebrafish
- Creators
- Emma Eklöf Ljunggren - Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, SwedenSabine Haupt - Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, SwedenJessica Ausborn - Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, SwedenKonstantinos Ampatzis - Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, SwedenAbdeljabbar El Manira - Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden
- Publication Details
- The Journal of neuroscience, v 34(1), pp 134-139
- Publisher
- Society for Neuroscience
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000329177800012
- Scopus ID
- 2-s2.0-84891433307
- Other Identifier
- 991014877826304721
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- Web of Science research areas
- Neurosciences