Journal article
Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion
Proceedings of the National Academy of Sciences - PNAS, v 110(28), pp 11589-11594
24 Jun 2013
PMID: 23798384
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neural networks in the spinal cord known as central pattern generators produce the sequential activation of muscles needed for locomotion. The overall locomotor network architectures in limbed vertebrates have been much debated, and no consensus exists as to how they are structured. Here, we use optogenetics to dissect the excitatory and inhibitory neuronal populations and probe the organization of the mammalian central pattern generator. We find that locomotor-like rhythmic bursting can be induced unilaterally or independently in flexor or extensor networks. Furthermore, we show that individual flexor motor neuron pools can be recruited into bursting without any activity in other nearby flexor motor neuron pools. Our experiments differentiate among several proposed models for rhythm generation in the vertebrates and show that the basic structure underlying the locomotor network has a distributed organization with many intrinsically rhythmogenic modules.
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Details
- Title
- Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion
- Creators
- Martin Hägglund - Karolinska InstitutetKimberly J. Dougherty - Karolinska InstitutetLotta Borgius - Karolinska InstitutetShigeyoshi Itohara - RIKEN Center for Brain ScienceTakuji Iwasato - National Institute of GeneticsOle Kiehn - Karolinska Institutet
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 110(28), pp 11589-11594
- Publisher
- National Academy of Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; College of Medicine; Drexel University
- Web of Science ID
- WOS:000321827000084
- Scopus ID
- 2-s2.0-84879907985
- Other Identifier
- 991020099800904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences