Journal article
Oral Tocotrienols Are Transported to Human Tissues and Delay the Progression of the Model for End-Stage Liver Disease Score in Patients
The Journal of nutrition, v 142(3), pp 513-519
01 Mar 2012
PMID: 22298568
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The natural vitamin E family is composed of 8 members equally divided into 2 classes: tocopherols (TCP) and tocotrienols (TE). A growing body of evidence suggests TE possess potent biological activity not shared by TCP. The primary objective of this work was to determine the concentrations of TE (200 mg mixed TE, b.i.d.) and TCP [200 mg alpha-TCP, b.i.d.)] in vital tissues and organs of adults receiving oral supplementation. Eighty participants were studied. Skin and blood vitamin E concentrations were determined from healthy participants following 12 wk of oral supplementation of TE or TCP. Vital organ vitamin E levels were determined by HPLC in adipose, brain, cardiac muscle, and liver of surgical patients following oral TE or TCP supplementation (mean duration, 20 wk; range, 1-96 wk). Oral supplementation of TE significantly increased the TE tissue concentrations in blood, skin, adipose, brain, cardiac muscle, and liver over time, alpha-TE was delivered to human brain at a concentration reported to be neuroprotective in experimental models of stroke. In prospective liver transplantation patients, oral TE lowered the model for end-stage liver disease (MELD) score in 50% of patients supplemented, whereas only 20% of TCP-supplemented patients demonstrated a reduction in MELD score. This work provides, to our knowledge, the first evidence demonstrating that orally supplemented TE are transported to vital organs of adult humans. The findings of this study, in the context of the current literature, lay the foundation for Phase II clinical trials testing the efficacy of TE against stroke and end-stage liver disease in humans. J. Nutr. 142: 513-519, 2012.
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Details
- Title
- Oral Tocotrienols Are Transported to Human Tissues and Delay the Progression of the Model for End-Stage Liver Disease Score in Patients
- Creators
- Viten Patel - The Ohio State UniversityCameron Rink - The Ohio State UniversityGayle M. Gordillo - The Ohio State UniversitySavita Khanna - The Ohio State UniversityUrmila Gnyawali - The Ohio State UniversitySashwati Roy - The Ohio State UniversityBassel Shneker - The Ohio State UniversityKasturi Ganesh - The Ohio State UniversityGary Phillips - The Ohio State UniversityJ. Layne More - The Ohio State UniversityAtom Sarkar - The Ohio State UniversityRobert Kirkpatrick - The Ohio State UniversityElmahdi A. Elkhammas - The Ohio State UniversityEmily Klatte - The Ohio State UniversityMichael Miller - The Ohio State UniversityMichael S. Firstenberg - The Ohio State UniversityE. Antonio Chiocca - The Ohio State UniversityKalanithi Nesaretnam - Malaysian Palm Oil BoardChandan K. Sen - The Ohio State University
- Publication Details
- The Journal of nutrition, v 142(3), pp 513-519
- Publisher
- Oxford Univ Press
- Number of pages
- 7
- Grant note
- NIH Roadmap for Medical Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Office of the Director, NIH (OD); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01NS042617 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Malaysian Palm Oil Board, an Institution of the Government of Malaysia TL1RR025753 / National Center for Research Resources; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) NS42617 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology; Neurosurgery
- Web of Science ID
- WOS:000300815900016
- Scopus ID
- 2-s2.0-84863408727
- Other Identifier
- 991021960812304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Nutrition & Dietetics