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Oral temafloxacin versus vancomycin for therapy of experimental endocarditis caused by methicillin-resistant Staphylococcus aureus
Journal article   Open access   Peer reviewed

Oral temafloxacin versus vancomycin for therapy of experimental endocarditis caused by methicillin-resistant Staphylococcus aureus

M T Hessen, P G Pitsakis and D Kaye
Antimicrobial agents and chemotherapy, v 34(6), pp 1143-1145
Jun 1990
DOI: https://doi.org/10.1128/aac.34.6.1143
PMID: 2393273
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1128/aac.34.6.1143View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

4-Quinolones Administration, Oral Animals Anti-Infective Agents - blood Anti-Infective Agents - pharmacokinetics Anti-Infective Agents - therapeutic use Drug Therapy, Combination - therapeutic use Endocarditis, Bacterial - drug therapy Fluoroquinolones Male Methicillin - pharmacology Microbial Sensitivity Tests Penicillin Resistance Quinolones Rats Rats, Inbred Strains Rifampin - therapeutic use Staphylococcal Infections - drug therapy Vancomycin - blood Vancomycin - pharmacokinetics Vancomycin - therapeutic use
We compared oral temafloxacin, a new fluoroquinolone agent, with vancomycin, each with and without rifampin, in the therapy of rats with aortic valve endocarditis caused by a clinical isolate of methicillin-resistant Staphylococcus aureus. The temafloxacin, vancomycin, and rifampin MICs and MBCs were 0.78 and 1.56, 1.56 and 3.13, and less than 0.024 and 0.78 microgram/ml, respectively. The animals were classified into the following six treatment groups: vancomycin (60 mg/kg) +/- rifampin (6 mg/kg) each intramuscularly every 12 h for 5 days; temafloxacin (100 mg/kg) orally +/- rifampin (6 mg/kg) intramuscularly every 12 h for 5 days; rifampin (6 mg/kg) intramuscularly every 12 h for 5 days; and untreated controls. All regimens with either vancomycin or temafloxacin resulted in improved survival over controls, but only temafloxacin regimens resulted in a significant reduction in bacterial counts in vegetations. These data support further investigation of the efficacy of temafloxacin in treating serious infections caused by methicillin-resistant S. aureus.

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Web of Science research areas
Microbiology
Pharmacology & Pharmacy
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