Journal article
Orbitofrontal sulcogyral morphology is a transdiagnostic indicator of brain dysfunction
NeuroImage clinical, v 17, pp 910-917
01 Jan 2018
PMID: 29527495
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Atypical sulcogyral patterns in the orbitofrontal cortex (OFC) are associated with increased risk for schizophrenia, as well as with quantitative traits associated with schizophrenia, such as anhedonia. Here we conduct a cross-diagnostic comparison to assess whether atypical OFC sulcogyral patterns confer risk for multiple brain disorders. We examined structural images from 4 groups of adult participants (N = 189), including those diagnosed with schizophrenia (SZ; N = 49), bipolar disorder (BP; N = 46), attention deficit hyperactivity disorder (ADHD; N = 41), and controls (N = 53). OFC sulcogyral pattern types were determined based on the continuity of the medial and lateral orbitofrontal sulcus. Chi-square analysis was performed to compare the sulcogyral pattern frequency distributions between patient groups and controls. We find that both SZ and BP groups had atypical pattern distributions, with increased atypical pattern frequencies relative to controls in the left hemisphere, consistent with the overlapping clinical features and genetic etiology of these disorders (SZ: χ
= 17.6; p < 0.001; BP: χ
= 19.2, p < 0.001). The ADHD group distribution did not significantly differ from controls (χ
= 5.5; p = 0.06, NS.). Similar sulcogyral pattern frequencies across BP and SZ suggest that the sulcogyral phenotype may map more directly to a trait that is transdiagnostic. These results suggest that sulcogyral patterns present a novel morphological indicator for increased susceptibility to multiple psychiatric diagnoses.
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Details
- Title
- Orbitofrontal sulcogyral morphology is a transdiagnostic indicator of brain dysfunction
- Creators
- Marisa A Patti - Autism & Developmental Medicine InstituteVanessa Troiani - Autism & Developmental Medicine Institute
- Publication Details
- NeuroImage clinical, v 17, pp 910-917
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000426180300095
- Scopus ID
- 2-s2.0-85039162548
- Other Identifier
- 991022005071104721
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- Web of Science research areas
- Neuroimaging