Aligned nanofibrous substrates can be created by electrospinning, but methods for creating multilamellar structures of aligned fibers are limited. Here, apposed nanofibrous scaffolds with pendant beta-cyclodextrin (CD) were adhered together by adamantane (Ad) modified hyaluronic acid, exploiting the guest-host interactions of CD and Ad for macroscopic assembly. Stable user-defined multi-layered scaffolds were formed for cell culture or tissue engineering.
Ordered, adherent layers of nanofibers enabled by supramolecular interactions
Creators
Christopher B. Highley - University of Pennsylvania
Christopher B. Rodell - University of Pennsylvania
Iris L. Kim - University of Pennsylvania
Ryan J. Wade - University of Pennsylvania
Jason A. Burdick - University of Pennsylvania
Publication Details
Journal of materials chemistry. B, Materials for biology and medicine, v 2(46), pp 8110-8115
Publisher
Royal Soc Chemistry
Number of pages
6
Grant note
R01EB008722 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB)
Graduate Research Fellowships
R01EB008722 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
DMR-1120901 / National Science Foundation through a MRSEC
R01AR056624 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
Resource Type
Journal article
Language
English
Academic Unit
School of Biomedical Engineering, Science, and Health Systems
Web of Science ID
WOS:000344990000008
Scopus ID
2-s2.0-84908593132
Other Identifier
991019176639904721
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