Journal article
Organization of Sensory Input to the Nociceptive-Specific Cutaneous Trunk Muscle Reflex in Rat, an Effective Experimental System for Examining Nociception and Plasticity
Journal of comparative neurology (1911), v 522(5), pp 1048-1071
01 Apr 2014
PMID: 23983104
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Detailed characterization of neural circuitries furthers our understanding of how nervous systems perform specific functions and allows the use of those systems to test hypotheses. We have characterized the sensory input to the cutaneous trunk muscle (CTM; also cutaneus trunci [rat] or cutaneus maximus [mouse]) reflex (CTMR), which manifests as a puckering of the dorsal thoracolumbar skin and is selectively driven by noxious stimuli. CTM electromyography and neurogram recordings in naive rats revealed that CTMR responses were elicited by natural stimuli and electrical stimulation of all segments from C4 to L6, a much greater extent of segmental drive to the CTMR than previously described. Stimulation of some subcutaneous paraspinal tissue can also elicit this reflex. Using a selective neurotoxin, we also demonstrate differential drive of the CTMR by trkA-expressing and nonexpressing small-diameter afferents. These observations highlight aspects of the organization of the CTMR system that make it attractive for studies of nociception and anesthesiology and plasticity of primary afferents, motoneurons, and the propriospinal system. We use the CTMR system to demonstrate qualitatively and quantitatively that experimental pharmacological treatments can be compared with controls applied either to the contralateral side or to another segment, with the remaining segments providing controls for systemic or other treatment effects. These data indicate the potential for using the CTMR system as both an invasive and a noninvasive quantitative assessment tool providing improved statistical power and reduced animal use. J. Comp. Neurol. 522:1048-1071, 2014. (c) 2013 Wiley Periodicals, Inc.
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Details
- Title
- Organization of Sensory Input to the Nociceptive-Specific Cutaneous Trunk Muscle Reflex in Rat, an Effective Experimental System for Examining Nociception and Plasticity
- Creators
- Jeffrey C. Petruska - University of LouisvilleDarrell F. Barker - Stony Brook SchoolSandra M. Garraway - Emory UniversityRobert Trainer - Stony Brook SchoolJames W. Fransen - University of LouisvillePeggy A. Seidman - Stony Brook SchoolRoy G. Soto - Stony Brook SchoolLorne M. Mendell - Stony Brook SchoolRichard D. Johnson - University of Florida
- Publication Details
- Journal of comparative neurology (1911), v 522(5), pp 1048-1071
- Publisher
- Wiley
- Number of pages
- 24
- Grant note
- Brain and Spinal Cord Injury Trust Fund of Florida 09-12A; 10-10 / Kentucky Spinal Cord and Head Injury Research Trust R01NS016996 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) SUNY-SB Department of Anesthesiology University of Florida Medical Guild P30GM103507 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) NS080091; NS016996; NS027511; P30GM103507 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Health Sciences
- Web of Science ID
- WOS:000331006700005
- Scopus ID
- 2-s2.0-84893790239
- Other Identifier
- 991022201755304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences
- Zoology