Journal article
Organization of the Mammalian Locomotor CPG: Review of Computational Model and Circuit Architectures Based on Genetically Identified Spinal Interneurons(1,2,3)
eNeuro, v 2(5), pENEURO.0069-15.2015
Sep 2015
PMID: 26478909
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The organization of neural circuits that form the locomotor central pattern generator (CPG) and provide flexor-extensor and left-right coordination of neuronal activity remains largely unknown. However, significant progress has been made in the molecular/genetic identification of several types of spinal interneurons, including V0 (V0D and V0V subtypes), V1, V2a, V2b, V3, and Shox2, among others. The possible functional roles of these interneurons can be suggested from changes in the locomotor pattern generated in mutant mice lacking particular neuron types. Computational modeling of spinal circuits may complement these studies by bringing together data from different experimental studies and proposing the possible connectivity of these interneurons that may define rhythm generation, flexor-extensor interactions on each side of the cord, and commissural interactions between left and right circuits. This review focuses on the analysis of potential architectures of spinal circuits that can reproduce recent results and suggest common explanations for a series of experimental data on genetically identified spinal interneurons, including the consequences of their genetic ablation, and provides important insights into the organization of the spinal CPG and neural control of locomotion.
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Details
- Title
- Organization of the Mammalian Locomotor CPG: Review of Computational Model and Circuit Architectures Based on Genetically Identified Spinal Interneurons(1,2,3)
- Creators
- Ilya A Rybak - Department of Neurobiology and Anatomy, Drexel University College of Medicine , Philadelphia, Pennsylvania 19129Kimberly J Dougherty - Department of Neurobiology and Anatomy, Drexel University College of Medicine , Philadelphia, Pennsylvania 19129Natalia A Shevtsova - Department of Neurobiology and Anatomy, Drexel University College of Medicine , Philadelphia, Pennsylvania 19129
- Publication Details
- eNeuro, v 2(5), pENEURO.0069-15.2015
- Publisher
- Society for Neuroscience; United States
- Grant note
- R01 NS095366 / NINDS NIH HHS R01 NS081713 / NINDS NIH HHS R01 NS090919 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000218574600006
- Scopus ID
- 2-s2.0-85044456620
- Other Identifier
- 991014878093904721
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- Web of Science research areas
- Neurosciences