Journal article
Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma
Blood, v 113(9), pp 1899-1905
26 Feb 2009
PMID: 19066394
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Organochlorine exposure was linked to non-Hodgkin lymphoma (NHL) risk. To determine whether this relation is modified by immune gene variation, we genotyped 61 polymorphisms in 36 immune genes in 1172 NHL cases and 982 controls from the National Cancer Institute–Surveillance, Epidemiology, and End Results (NCI-SEER) study. We examined 3 exposures with elevated risk in this study: PCB180 (plasma, dust measurements), the toxic equivalency quotient (an integrated functional measure of several organochlorines) in plasma, and α-chlordane (dust measurements, self-reported termiticide use). Plasma (100 cases, 100 controls) and dust (682 cases, 513 controls) levels were treated as natural log-transformed continuous variables. Unconditional logistic regression was used to calculate β coefficients and odds ratios, stratified by genotype. Associations between all 3 exposures and NHL risk were limited to the same genotypes for IFNG (C−1615T) TT and IL4 (5′-UTR, Ex1-168C>T) CC. Associations between PCB180 in plasma and dust and NHL risk were limited to the same genotypes for IL16 (3′-UTR, Ex22+871A>G) AA, IL8 (T−251A) TT, and IL10 (A−1082G) AG/GG. This shows that the relation between organochlorine exposure and NHL risk may be modified by particular variants in immune genes and provides one of the first examples of a potential gene-environment interaction for NHL.
Metrics
Details
- Title
- Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma
- Creators
- Joanne S. Colt - National Institutes of HealthNathaniel Rothman - National Institutes of HealthRichard K. Severson - The Barbara Ann Karmanos Cancer InstitutePatricia Hartge - National Institutes of HealthJames R. Cerhan - Mayo ClinicNilanjan Chatterjee - National Institutes of HealthWendy Cozen - University of Southern CaliforniaLindsay M. Morton - National Institutes of HealthAnneclaire J. De Roos - University of WashingtonScott Davis - University of WashingtonStephen Chanock - Department of Health and Human ServicesSophia S. Wang - National Institutes of Health
- Publication Details
- Blood, v 113(9), pp 1899-1905
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000263723700006
- Scopus ID
- 2-s2.0-61849090772
- Other Identifier
- 991020100214604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Hematology