Journal article
Origin of excitation underlying locomotion in the spinal circuit of zebrafish
Proceedings of the National Academy of Sciences - PNAS, v 109(14), pp 5511-5516
03 Apr 2012
PMID: 22431619
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neural circuits in the spinal cord transform instructive signals from the brain into well-coordinated locomotor movements by virtue of rhythm-generating components. Although evidence suggests that excitatory interneurons are the essence of locomotor rhythm generation, their molecular identity and the assessment of their necessity have remained unclear. Here we show, using larval zebrafish, that V2a interneurons represent an intrinsic source of excitation necessary for the normal expression of the locomotor rhythm. Acute and selective ablation of these interneurons increases the threshold of induction of swimming activity, decreases the burst frequency, and alters the coordination of the rostro-caudal propagation of activity. Thus, our results argue that V2a interneurons represent a source of excitation that endows the spinal circuit with the capacity to generate locomotion.
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Details
- Title
- Origin of excitation underlying locomotion in the spinal circuit of zebrafish
- Creators
- Emma Eklof-Ljunggren - Karolinska InstitutetSabine Haupt - Karolinska InstitutetJessica Ausborn - Karolinska InstitutetIvar Dehnisch - Karolinska InstitutetPer Uhlen - Karolinska InstitutetShin-ichi Higashijima - Natl Inst Nat Sci, Okazaki Inst Integrat Biosci, Natl Inst Physiol Sci, Okazaki, Aichi 4448787, JapanAbdeljabbar El Manira - Karolinska Institutet
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 109(14), pp 5511-5516
- Publisher
- Natl Acad Sciences
- Number of pages
- 6
- Grant note
- German Research Foundation; German Research Foundation (DFG) European Commission; European Commission Joint Research Centre Karolinska Institutet Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000302294700079
- Scopus ID
- 2-s2.0-84859460540
- Other Identifier
- 991020655544904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences