Journal article
Origin of nanomechanical cantilever motion generated from biomolecular interactions
Proceedings of the National Academy of Sciences - PNAS, v 98(4), pp 1560-1564
13 Feb 2001
PMID: 11171990
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Generation of nanomechanical cantilever motion from biomolecular
interactions can have wide applications, ranging from high-throughput
biomolecular detection to bioactuation. Although it has been suggested
that such motion is caused by changes in surface stress of a cantilever
beam, the origin of the surface-stress change has so far not been
elucidated. By using DNA hybridization experiments, we show that the
origin of motion lies in the interplay between changes in
configurational entropy and intermolecular energetics induced by
specific biomolecular interactions. By controlling entropy change
during DNA hybridization, the direction of cantilever motion can be
manipulated. These thermodynamic principles were also used to explain
the origin of motion generated from protein–ligand binding.
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Details
- Title
- Origin of nanomechanical cantilever motion generated from biomolecular interactions
- Creators
- Guanghua Wu - Department of Mechanical Engineering, University of California, Berkeley, CA 94720Haifeng Ji - Department of Mechanical Engineering, University of California, Berkeley, CA 94720Karolyn Hansen - Department of Mechanical Engineering, University of California, Berkeley, CA 94720Thomas Thundat - Department of Mechanical Engineering, University of California, Berkeley, CA 94720Ram Datar - Department of Mechanical Engineering, University of California, Berkeley, CA 94720Richard Cote - Department of Mechanical Engineering, University of California, Berkeley, CA 94720Michael F Hagan - Department of Mechanical Engineering, University of California, Berkeley, CA 94720Arup K Chakraborty - Department of Mechanical Engineering, University of California, Berkeley, CA 94720Arunava Majumdar - Department of Mechanical Engineering, University of California, Berkeley, CA 94720
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 98(4), pp 1560-1564
- Publisher
- The National Academy of Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000166949200047
- Scopus ID
- 2-s2.0-0035852777
- Other Identifier
- 991014877906304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology