Journal article
Oropharyngeal Candidiasis in Patients with AIDS: Randomized Comparison of Fluconazole Versus Nystatin Oral Suspensions
Clinical infectious diseases, v 24(6), pp 1204-1207
Jun 1997
PMID: 9195083
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A total of 167 human immunodeficiency virus (HIV)-infected patients with oropharyngeal candidiasis were randomly assigned to receive 14 days of therapy with liquid suspension fluconazole (100 mg once daily) or liquid nystatin (500,000 U four times daily). At day 14, 87% of the fluconazole-treated patients were clinically cured, as opposed to 52% in the nystatin-treated group (P < .001). Fluconazole eradicated Candida organisms from the oral flora in 60%, vs. a 6% eradication rate with nystatin (P < .001). The fluconazole group had fewer relapses noted on day 28 (18%, vs. 44% in the nystatin group; P < .001). This relapse difference no longer existed by day 42. Fluconazole oral suspension as a systemic therapy was more effective than liquid nystatin as a topical therapy in the treatment of oral candidiasis in HIV-infected patients and provided a longer disease-free interval before relapse.
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Details
- Title
- Oropharyngeal Candidiasis in Patients with AIDS: Randomized Comparison of Fluconazole Versus Nystatin Oral Suspensions
- Creators
- Vincent Pons - University of California, San FranciscoDeborah Greenspan - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New YorkFrancina Lozada-Nur - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New YorkLaurie McPhail - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New YorkJoel E. Gallant - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New YorkAllan Tunkel - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New YorkCaroline C. Johnson - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New YorkJames McCarty - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New YorkHelene Panzer - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New YorkMarcia Levenstein - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New YorkAnnella Barranco - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New YorkStephen Green - Division of Infectious Disease and the Department of Stomatology, University of California Hospital, San Francisco, California, Philadelphia, Pennsylvania, Fresno, California, New York, New York
- Publication Details
- Clinical infectious diseases, v 24(6), pp 1204-1207
- Publisher
- The University of Chicago Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medical College of Pennsylvania and Hahnemann University (1993-1996, 1998-2002); Dana and David Dornsife School of Public Health
- Web of Science ID
- WOS:A1997XE36600029
- Scopus ID
- 2-s2.0-0030927488
- Other Identifier
- 991019168305604721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology