Journal article
Orthopaedic biofilm infections
Current orthopaedic practice, v 22(6), pp 558-563
Nov 2011
PMID: 22323927
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A recent paradigm shift in microbiology affects orthopaedic surgery and most other medical and dental disciplines because more than 65% of bacterial infections treated by clinicians in the developed world are now known to be caused by organisms growing in biofilms. These slime-enclosed communities of bacteria are inherently resistant to host defenses and to conventional antibacterial therapy, and these device-related and other chronic bacterial infections are unaffected by the vaccines and antibiotics that have virtually eliminated acute infections caused by planktonic (floating) bacteria. We examine the lessons that can be learned, within this biofilm paradigm, by the study of problems (e.g. non-culturability) shared by all biofilm infections and by the study of new therapeutic options aimed specifically at sessile bacteria in biofilms. Orthopaedic surgery has deduced some of the therapeutic strategies based on assiduous attention to patient outcomes, but much can still be learned by attention to modern research in related disciplines in medicine and dentistry. These perceptions will lead to practical improvements in the detection, management, and treatment of infections in orthopaedic surgery.
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Details
- Title
- Orthopaedic biofilm infections
- Creators
- Paul Stoodley - National Centre for Advanced Tribology, University of Southampton, Southampton, UKGarth D EhrlichParish P Sedghizadeh - Department of Oral and Maxillofacial Surgery, Dental School, University of Southern California, Los Angeles CALuanne Hall-Stoodley - School of Medicine, University of Southampton, Southampton, UKMark E Baratz - Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PADaniel T Altman - Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PANicholas G Sotereanos - Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PAJohn William Costerton - Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PAPatrick DeMeo - Center for Genomic Science, Allegheny General Hospital, Pittsburgh, PA
- Publication Details
- Current orthopaedic practice, v 22(6), pp 558-563
- Publisher
- Lippincott
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; Orthopedic/Orthopaedic Surgery
- Web of Science ID
- WOS:000217826200015
- Scopus ID
- 2-s2.0-82955219636
- Other Identifier
- 991014878116504721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Orthopedics