Journal article
Osmotic stimulation of vasopressin mRNA content in the supraoptic nucleus requires synaptic activation
American journal of physiology. Regulatory, integrative and comparative physiology, v 268(4), pp R1034-R1039
Apr 1995
PMID: 7733386
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The role of synaptic input to the vasopressin neurons in hypertonicity-induced increase in vasopressin mRNA content was evaluated. Synaptic connection with the anterior hypothalamus is required for hypertonicity to increase vasopressin release. However, the potential for other mechanisms to induce the increase in vasopressin mRNA content is suggested by the fact that hypertonicity induces depolarization of supraoptic neurons independently of synaptic input. Explants of the hypothalamoneurohypophysial system were used to study the effect of depolarization and hypertonicity in the presence and absence of nonspecific synaptic blockade by 15 mM MgSO4 or blockade of excitatory amino acid receptors with kynurenic acid. Vasopressin release and mRNA content were increased by depolarization with 40 mM KCl and by exposure to hypertonicity (P < 0.05). Basal and osmotically stimulated vasopressin release was decreased by MgSO4 and by kynurenic acid. Both agents prevented the hypertonicity-induced increase in vasopressin mRNA content. Thus either synaptic input or increased VP release is required for hypertonicity to increase vasopressin mRNA, and excitatory amino acids are implicated in this response.
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Details
- Title
- Osmotic stimulation of vasopressin mRNA content in the supraoptic nucleus requires synaptic activation
- Creators
- C. D. Sladek - Rosalind Franklin University of Medicine and ScienceK. Y. Fisher - Rosalind Franklin University of Medicine and ScienceH. E. Sidorowicz - Rosalind Franklin University of Medicine and ScienceJ. R. Mathiasen - Rosalind Franklin University of Medicine and Science
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, v 268(4), pp R1034-R1039
- Publisher
- AMER PHYSIOLOGICAL SOC; BETHESDA
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1995QR99300027
- Scopus ID
- 2-s2.0-0028923356
- Other Identifier
- 991021900194804721
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- Web of Science research areas
- Physiology