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Journal article
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Bone research, v 5(1), pp 16044-16044
17 Jan 2017
PMID: 28149655
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes.
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Details
- Title
- Osteoarthritis: toward a comprehensive understanding of pathological mechanism
- Creators
- Di Chen - Rush University Medical CenterJie Shen - Washington University in St. LouisWeiwei Zhao - Li Ka Shing Faculty of Medicine, University of Hong KongTingyu Wang - Shanghai Ninth People's HospitalLin Han - Drexel UniversityJohn L Hamilton - Rush University Medical CenterHee-Jeong Im - Rush University Medical Center
- Publication Details
- Bone research, v 5(1), pp 16044-16044
- Publisher
- Nature Publishing Group
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000401226100001
- Scopus ID
- 2-s2.0-85009841292
- Other Identifier
- 991019168127804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell & Tissue Engineering