Journal article
Osteoblast Attachment on Biomaterials as a Function of Surface Charge
MRS proceedings, v 550, pp 121-126
01 Jan 1999
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Bioactive materials such as calcium phosphate ceramics and bioactive glasses enhance bone tissue formation and then bond to bone tissue. In our work, we question what particular surface feature or features of bioactive materials are responsible for the bone tissue response. In this study we have uncoupled surface charge from surface chemistry, energy, and topography and have examined osteoblast adhesion to titanium surfaces of varying surface charge. We have shown that a negative surface charge promotes osteoblast adhesion by approximately 60% over a neutral surface and that conversely, a positive surface charge inhibits osteoblast adhesion by about 20%. Continued examination of surface characteristics that control cellular responses are warranted with the eventual goal of applying those desirable surface characteristics to any structural biomaterial for bone implant or tissue engineering applications.
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Details
- Title
- Osteoblast Attachment on Biomaterials as a Function of Surface Charge
- Creators
- M Marcolongo - Drexel UniversityN DiNardo - Drexel UniversityN Hickok - Thomas Jefferson UniversityR Tuan - Thomas Jefferson UniversityK Pourezzaei - Drexel UniversityR Beard - Drexel UniversityD Brennan - Drexel UniversityP Heipp - Drexel UniversityT Phan - Drexel University
- Publication Details
- MRS proceedings, v 550, pp 121-126
- Publisher
- Cambridge University Press
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:000080751700019
- Other Identifier
- 991019170369904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Materials Science, Biomaterials
- Materials Science, Multidisciplinary
- Pharmacology & Pharmacy