Journal article
Otitis media : Interactions between host and environment, immune and inflammatory responses
International journal of pediatric otorhinolaryngology, v 176, pp 111798-111798
2024
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To review and highlight progress in otitis media (OM) research in the areas of immunology, inflammation, environmental influences and host-pathogen responses from 2019 to 2023. Opportunities for innovative future research were also identified. Data sources: PubMed database of the National Library of Medicine. Review methods: Key topics were assigned to each panel member for detailed review. Search of the literature was from June 2019 until February 2023. Draft reviews were collated, circulated, and discussed among panel members at the 22nd International Symposium on Recent Advances in Otitis Media in June 2023. The final manuscript was prepared and approved by all the panel members. Conclusions: Important advances were identified in: environmental influences that enhance OM susceptibility; polymicrobial middle ear (ME) infections; the role of adaptive immunity defects in otitis-proneness; additional genes linked to OM; leukocyte contributions to OM pathogenesis and recovery; and novel interventions in OM based on host responses to infection. Innovative areas of research included: identification of novel bacterial genes and pathways important for OM persistence, bacterial adaptations and evolution that enhance chronicity; animal and human ME gene expression, including at the single-cell level; and Sars-CoV-2 infection of the ME and Eustachian tube.
Metrics
Details
- Title
- Otitis media : Interactions between host and environment, immune and inflammatory responses
- Creators
- Johanna Nokso-Koivisto - Helsinki University HospitalGarth D. Ehrlich - Drexel UniversityFrida Enoksson - Lund UniversityKensei Komatsu - Georgia State UniversityKevin Mason - Nationwide Children's HospitalÅsa Melhus - Uppsala UniversityJanak A. Patel - The University of Texas Medical Branch at GalvestonShiyan Vijayasekaran - The University of Western AustraliaAllen Ryan - University of California San Diego
- Publication Details
- International journal of pediatric otorhinolaryngology, v 176, pp 111798-111798
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:001131560000001
- Scopus ID
- 2-s2.0-85178133912
- Other Identifier
- 991021811732104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Otorhinolaryngology
- Pediatrics