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Outbreak of poliomyelitis-like paralysis associated with enterovirus 71
Journal article   Peer reviewed

Outbreak of poliomyelitis-like paralysis associated with enterovirus 71

JEAN Hayward, SHEILA Gillespie, KAREN Kaplan, ROGER Packer, MARK Pallansch, STANLEY Plotkin and LAWRENCE Schonberger
The Pediatric infectious disease journal, v 8(9), pp 611-615
Sep 1989
DOI: https://doi.org/10.1097/00006454-198909000-00009
PMID: 2797956
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

In the summer of 1987 five children were seen at The Childrenʼs Hospital of Philadelphia because of acute onset of flaccid paralysis of an arm or leg(s). Although there were documented exposures to oral poliovirus vaccine and coxsackievirus B3 in some of the cases, the clinical, epidemiologic and laboratory findings indicate that enterovirus 71 was the common etiologic agent for this unusual outbreak of poliomyelitislike paralysis. Of the five children three recovered completely; the other two had residual paralysis with weakness and muscle wasting. Imaging studies of the spinal cord in the two children with residual paralysis revealed defects in the ventral aspect of the spinal cord. This series of paralytic cases attributed to enterovirus 71 is the largest reported in the United States.

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106 citations in Web of Science
117 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Immunology
Infectious Diseases
Pediatrics
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