Journal article
Outcomes of stereotactic radiosurgery for pituitary metastases: an international multi-institutional study
Pituitary, v 28(3), p69
01 Jun 2025
PMID: 40442537
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pituitary metastases (PM) account for 0.4% of all intracranial metastases and typically present with visual and endocrinological deficits. Stereotactic radiosurgery (SRS) has shown excellent tumor control and safety profile in the management of intracranial metastases. However, its role and safety in managing metastases to the pituitary gland are not well-characterized. This study aims to evaluate SRS outcomes and safety profile in the management of PM in a multicenter international cohort.
The authors retrospectively analyzed data from 63 patients with PM treated with SRS across 12 institutions, assessing clinical and radiological outcomes, including survival rates, tumor control, visual and endocrinological outcomes, and post-treatment complications.
Among 63 patients included in the study (median tumor volume: 1.5 cc), SRS demonstrated a local tumor control rate of 93.1% at 12 months. The median survival was 25.4 months and overall survival rates of 77.6%, 65.9%, and 55.1% at 6, 12, and 18 months, respectively. In multivariate analysis, a margin dose for PM > 10 Gy emerged as an independent predictor across progression-free survival (HR: 0.20, p < 0.01), distant metastasis-free survival (HR: 0.30, p = 0.01), and overall survival. (HR: 0.15, p < 0.01). Following SRS, most patients showed stable or improved visual function (n = 17/18). A small percentage of patients experienced complications: developed new visual deficits (n = 1/63), experienced new anterior pituitary hormone deficiency (n = 5/63), and developed arginine vasopressin (AVP)-deficiency post-treatment (n = 2/63).
SRS is an important modality in the management of PM, offering excellent local tumor control and survival outcomes with minimal morbidity. These findings support the incorporation of SRS into the multidisciplinary management for treating patients with PM.
Metrics
2 Record Views
Details
- Title
- Outcomes of stereotactic radiosurgery for pituitary metastases: an international multi-institutional study
- Creators
- Hussam Abou-Al-Shaar - University of Pittsburgh Medical CenterIbrahem Albalkhi - University of Pittsburgh Medical CenterRimsha K Shariff - University of Pittsburgh Medical CenterArka N Mallela - University of Pittsburgh Medical CenterPouneh K Fazeli - University of Pittsburgh Medical CenterSalem M Tos - University of VirginiaGeorgios Mantziaris - Neurological SurgeryYing Meng - NYU Langone HealthKenneth Bernstein - NYU Langone HealthTehila Kaisman-Elbaz - Sheba Medical CenterHanan Abofani - Sheba Medical CenterYen-Yu Lin - Taipei Veterans General HospitalCheng-Chia Lee - Taipei Veterans General HospitalManjul Tripathi - Post Graduate Institute of Medical Education and ResearchRituraj Upadhyay - The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteJoshua D Palmer - The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteAhmed M Nabeel - Nasser Institute hospitalWael A Reda - Benha UniversitySameh R Tawadros - Nasser Institute hospitalKhaled Abdelkarim - Ain Shams UniversityAmr M N El-Shehaby - Benha UniversityReem M Emad - Nasser Institute hospitalSelcuk Peker - Koç UniversityYavuz Samanci - Koç UniversityRodney E Wegner - Allegheny Health NetworkMatthew J Shepard - Allegheny Health NetworkRoman Liscak - Na Homolce HospitalGabriela Simonova - University of British ColumbiaTimoteo Almeida - University of British ColumbiaCarolina Benjamin - University of Miami Health SystemDouglas Kondziolka - NYU Langone HealthJason P Sheehan - Neurological SurgeryAjay Niranjan - University of Pittsburgh Medical CenterConstantinos G Hadjipanayis - University of Pittsburgh Medical CenterL Dade Lunsford - University of Pittsburgh Medical Center
- Publication Details
- Pituitary, v 28(3), p69
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:001501643000001
- Scopus ID
- 2-s2.0-105006900146
- Other Identifier
- 991022154807504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Endocrinology & Metabolism